ArticleExperimental neurology2009
Neurotransmitter regulation of c-fos and vasopressin gene expression in the rat supraoptic nucleus.
Article in Experimental neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice.PloS one · 2026Article
- Peripheral viral challenge increases c-fos level in cerebral neurons.Metabolic brain disease · 2021Article
- Anatomical Markers of Activity in Hypothalamic Neurons.Comprehensive Physiology · 2020Review
- Effects of Probiotic Supplementation on Short Chain Fatty Acids in the AppNL-G-F Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2020Article
- Angiotensin II Type 1a Receptors in the Subfornical Organ Modulate Neuroinflammation in the Hypothalamic Paraventricular Nucleus in Heart Failure Rats.Neuroscience · 2018Article
- Attenuated hypothalamic responses to α-melanocyte stimulating hormone during pregnancy in the rat.The Journal of physiology · 2016Article
- A RNA-Seq Analysis of the Rat Supraoptic Nucleus Transcriptome: Effects of Salt Loading on Gene Expression.PloS one · 2015Article
- ANG II receptor subtype 1a gene knockdown in the subfornical organ prevents increased drinking behavior in bile duct-ligated rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylation.Peptides · 2012Article
- ΔFosB in the supraoptic nucleus contributes to hyponatremia in rats with cirrhosis.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Region-specific changes in transient receptor potential vanilloid channel expression in the vasopressin magnocellular system in hepatic cirrhosis-induced hyponatraemia.Journal of neuroendocrinology · 2012Article
- Effects of A-CREB, a dominant negative inhibitor of CREB, on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo.Brain research · 2012Article
- G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis.Frontiers in neuroendocrinology · 2012Review
- Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Intron-specific neuropeptide probes.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Fos proteins are not prerequisite for osmotic induction of vasopressin transcription in supraoptic nucleus of rats.Neuroscience letters · 2010Article
- Expression of the nuclear transport protein importin ß-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge.Neuroscience · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Acute increases in plasma osmotic pressure produced by intraperitoneal injection of hypertonic NaCl are sensed by osmoreceptors in the brain, which excite the magnocellular neurons (MCNs) in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) in the hypothalamus inducing the secretion of vasopressin (VP) into the general circulation. Such systemic osmotic stimulation also causes rapid and transient increases in the gene expression of c-fos and VP in the MCNs. In this study we evaluated potential signals that might be responsible for initiating these gene expression changes during acute hyperosmotic stimulation. We use an in vivo paradigm in which we stereotaxically deliver putative agonists and antagonists over the SON unilaterally, and use the contralateral SON in the same rat, exposed only to vehicle solutions, as the control SON. Quantitative real time-PCR was used to compare the levels of c-fos mRNA, and VP mRNA and VP heteronuclear (hn)RNA in the SON. We found that the ionotropic glutamate agonists (NMDA plus AMPA) caused an approximately 6-fold increase of c-fos gene expression in the SON, and some, but not all, G-coupled protein receptor agonists (e.g., phenylephrine, senktide, a NK-3-receptor agonist, and alpha-MSH) increased the c-fos gene expression in the SON from between 1.5 to 2-fold of the control SONs. However, none of these agonists were effective in increasing VP hnRNA as is seen with acute salt-loading. This indicates that the stimulus-transcription coupling mechanisms that underlie the c-fos and VP transcription increases during acute osmotic stimulation differ significantly from one another.
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