ArticleExperimental hematology2009
Absence of alpha 4 but not beta 2 integrins restrains development of chronic allergic asthma using mouse genetic models.
Article in Experimental hematology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin.American journal of respiratory cell and molecular biology · 2013Trial
- Adaptive Immunity and Pathogenesis of Diabetes: Insights Provided by the α4-Integrin Deficient NOD Mouse.Cells · 2020Article
- Clinical implications of CD4Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2018Article
- Activation states of blood eosinophils in asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Review
- Anti-IL-5 attenuates activation and surface density of β(2) -integrins on circulating eosinophils after segmental antigen challenge.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2013Article
- Role of T cells in a gp91phox knockout murine model of acute allergic asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2013Article
- Integrin activation States and eosinophil recruitment in asthma.Frontiers in pharmacology · 2013Article
- Platelet activation, P-selectin, and eosinophil β1-integrin activation in asthma.American journal of respiratory and critical care medicine · 2012Article
- Defining the molecular role of gp91phox in the immune manifestation of acute allergic asthma using a preclinical murine model.Clinical and molecular allergy : CMA · 2012Article
- Triple selectin knockout (ELP-/-) mice fail to develop OVA-induced acute asthma phenotype.Journal of inflammation (London, England) · 2011Article
- Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Combinatorial and distinct roles of α₅ and α₄ integrins in stress erythropoiesis in mice.Blood · 2011Article
- Dissecting asthma pathogenesis through study of patterns of cellular traffic indicative of molecular switches operative in inflammation.Progress in stem cellArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveChronic asthma is characterized by ongoing recruitment of inflammatory cells and airway hyperresponsiveness leading to structural airway remodeling. Although alpha 4 beta 1 and beta2 integrins regulate leukocyte migration in inflammatory diseases and play decisive roles in acute asthma, their role has not been explored under the chronic asthma setting. To extend our earlier studies with alpha 4(Delta/Delta) and beta2(-/-) mice, which showed that both alpha 4 and beta2 integrins have nonredundant regulatory roles in acute ovalbumin (OVA)-induced asthma, we explored to what extent these molecular pathways control development of structural airway remodeling in chronic asthma. MATERIALS AND
methodsControl, alpha 4(Delta/Delta), and beta2(-/-) mouse groups, sensitized by intraperitoneal OVA as allergen, received intratracheal OVA periodically over days 8 to 55 to induce a chronic asthma phenotype. Post-OVA assessment of inflammation and pulmonary function (airway hyperresponsiveness), together with airway modeling measured by goblet cell metaplasia, collagen content of lung, and transforming growth factor beta1 expression in lung homogenates, were evaluated.
resultsIn contrast to control and beta2(-/-) mice, alpha 4(Delta/Delta) mice failed to develop and maintain the composite chronic asthma phenotype evaluated as mentioned and subepithelial collagen content was comparable to baseline. These data indicate that beta2 integrins, although required for inflammatory migration in acute asthma, are dispensable for structural remodeling in chronic asthma.
conclusionalpha 4 integrins appear to have a regulatory role in directing transforming growth factor beta-induced collagen deposition and structural alterations in lung architecture likely through interactions of Th2 cells, eosinophils, or mast cells with endothelium, resident airway cells, and/or extracellular matrix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.