ArticleVirus research2009
Murine norovirus-1 entry into permissive macrophages and dendritic cells is pH-independent.
Article in Virus research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions.Communications biology · 2022Article
- Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses.Frontiers in immunology · 2022Article
- Review
- Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways.PLoS pathogens · 2021Article
- CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus.Journal of virology · 2021Article
- Norovirus Attachment and Entry.Viruses · 2019Review
- Review
- Article
- Article
- Porcine sapovirus Cowden strain enters LLC-PK cells via clathrin- and cholesterol-dependent endocytosis with the requirement of dynamin II.Veterinary research · 2018Article
- Transcriptomic analysis of human norovirus NS1-2 protein highlights a multifunctional role in murine monocytes.BMC genomics · 2017Article
- Recent advances in understanding noroviruses.F1000Research · 2017Review
- Current tools for norovirus drug discovery.Expert opinion on drug discovery · 2016Review
- Endosomal acidification and cathepsin L activity is required for calicivirus replication.Virology · 2014Article
- Norovirus: targets and tools in antiviral drug discovery.Biochemical pharmacology · 2014Review
- Murine norovirus transcytosis across an in vitro polarized murine intestinal epithelial monolayer is mediated by M-like cells.Journal of virology · 2013Article
- High-resolution functional profiling of the norovirus genome.Journal of virology · 2012Article
- Mouse norovirus 1 utilizes the cytoskeleton network to establish localization of the replication complex proximal to the microtubule organizing center.Journal of virology · 2012Article
- Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response.PLoS pathogens · 2012Article
- Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol.Journal of virology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Murine norovirus (MNV) is a recently discovered mouse pathogen. Unlike the fastidious human noroviruses that cause the overwhelming majority of non-bacterial gastroenteritis worldwide, MNV readily infects cells in culture. Its replication in primary murine macrophages and dendritic cells and their derived cell lines allows the study of norovirus cell entry for the first time. In this study we determined the role of pH during MNV-1 infection since the low pH environment of endosomes often triggers uncoating of viruses. We demonstrated that MNV-1 viral titers by plaque assay and expression of the non-structural protein VPg by immunofluorescence were not affected by pH in cultured and primary macrophages and dendritic cells in the presence of two known endosome acidification inhibitors, bafilomycin A1 and chloroquine. These data indicate that MNV-1 enters permissive cells in a pH-independent manner.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.