ArticleProceedings of the National Academy of Sciences of the United States of America1991
Characterization and mapping of human genes encoding zinc finger proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Establishment of a monoclonal antibody against a peptide of the novel zinc finger protein ZNF32 proved to be specific and sensitive for immunological measurements.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Thyroid transcription factor-1 (TTF-1) gene: identification of ZBP-89, Sp1, and TTF-1 sites in the promoter and regulation by TNF-α in lung epithelial cells.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes.PloS one · 2010Article
- Molecular and developmental biology of the hemangioblast.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Review
- Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells.Environmental health perspectives · 2005Article
- A Krüppel-like zinc finger protein is involved in nitrogen-fixing root nodule organogenesis.Genes & development · 2000Article
- Cys2/His2 zinc-finger protein family of petunia: evolution and general mechanism of target-sequence recognition.Nucleic acids research · 1998Article
- Isolation and characterisation of a diverse family of Arabidopsis two and three-fingered C2H2 zinc finger protein genes and cDNAs.Plant molecular biology · 1997Article
- ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter.Molecular and cellular biology · 1996Article
- Isolation by PCR of a cDNA clone from pea petals with similarity to petunia and wheat zinc finger proteins.Plant molecular biology · 1996Article
- From repression domains to designer zinc finger proteins: a novel strategy of intracellular immunization against HIV.Gene expression · 1996Article
- Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19.Human genetics · 1993Article
- Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24.Human genetics · 1993Article
- A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zinc finger motif, exemplified by a segment of the Drosophila gap gene Krüppel, is a nucleic acid-binding domain present in many transcription factors. To investigate the gene family encoding this motif in the human genome, a placental genomic library was screened at moderate stringency with a degenerate oligodeoxynucleotide probe designed to hybridize to the His/Cys (H/C) link region between adjoining zinc fingers. Over 200 phage clones were obtained and are being sorted into groups by partial sequencing, cross-hybridization with oligodeoxynucleotide probes, and PCR amplification. Further, the genomic clones were cross-hybridized with a set of 30 zinc finger-encoding cDNAs (Kox1-Kox30) isolated from a human T-cell cDNA library. Four cDNAs (Kox4, Kox7, Kox12, and Kox15) were identified that match one or more genomic clones; these matches were confirmed by nucleotide sequence analysis. One or more clones from each locus were mapped onto human metaphase chromosomes by chromosomal in situ suppression hybridization with fluorescent probe detection. We mapped ZNF7/Kox4 to chromosome 8qter, ZNF19/Kox12 to 16q22, ZNF22/Kox15 to 10q11, and ZNF44/Kox7 to 16p11. The results of these analyses support the conclusion that the human genome contains many, probably several hundred, zinc finger genes with consensus H/C link regions.
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