ArticlePharmacology, biochemistry, and behavior2009
Novelty modulates the stimulating motor effects of ethanol in preweanling rats.
Article in Pharmacology, biochemistry, and behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- C57BL/6J offspring mice reared by a single-mother exhibit, compared to mice reared in a biparental parenting structure, distinct neural activation patterns and heightened ethanol-induced anxiolysis.Psychopharmacology · 2025Article
- Response to novelty and cocaine stimulant effects: lack of stability across environments in female Swiss mice.Psychopharmacology · 2016Article
- Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.Behavioural brain research · 2013Article
- μ-Opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation.Pharmacology, biochemistry, and behavior · 2013Article
- Role of mu, delta and kappa opioid receptors in ethanol-reinforced operant responding in infant rats.Behavioural brain research · 2012Article
- Chronic tolerance to the locomotor stimulating effect of ethanol in preweanling rats as a function of social stress.Alcohol (Fayetteville, N.Y.) · 2012Article
- Mianserin, but not ondansetron, reduces the locomotor stimulating effect of ethanol in preweanling rats.Pharmacology, biochemistry, and behavior · 2011Article
- A comparison between taste avoidance and conditioned disgust reactions induced by ethanol and lithium chloride in preweanling rats.Developmental psychobiology · 2010Article
- Social isolation and stress related hormones modulate the stimulating effect of ethanol in preweanling rats.Behavioural brain research · 2010Article
- Differential role of mu, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.Physiology & behavior · 2010Article
- Dopamine receptors modulate ethanol's locomotor-activating effects in preweanling rats.Developmental psychobiology · 2010Article
- Ethanol-mediated aversive learning as a function of locomotor activity in a novel environment in infant Sprague-Dawley rats.Pharmacology, biochemistry, and behavior · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
During early ontogeny heterogeneous rats are sensitive to ethanol's stimulating effects. In adulthood locomotor activity in a novel environment is a valuable predictor of acute sensitivity to the activating effects of various drugs, including ethanol. Environmental novelty modulates response to ethanol and other drugs in adult rats. The present study analyzed the role of novelty in the acute locomotor response induced by ethanol earlier in development, during the preweanling period, a stage characterized by enhanced sensitivity to ethanol's reinforcing effects. In Experiment 1 we evaluated the predictive value of baseline locomotor activity upon ethanol-induced locomotor effects in 12-day-old rats. In Experiment 2 we tested whether repeated familiarization with the testing environment would reduce the stimulating effects induced by ethanol on postnatal day 12. Individual differences in response to an inescapable novel environment significantly predicted the locomotor activating effects of ethanol, but not other acute effects of the drug, such as hypothermia, motor impairment or sedation. Behavioral activation induced by ethanol during the preweanling period was attenuated after familiarization with the testing environment, suggesting that environmental novelty is critical for activating effects of ethanol.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.