ReviewCurrent gastroenterology reports2009
Dilated intercellular spaces as a marker of GERD.
Review in Current gastroenterology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study.World journal of gastroenterology · 2015Trial
- A gene therapy approach to prevent dilated intercellular space, a hallmark of gastroesophageal reflux disease.Gene therapy · 2026Article
- Exploring the link between glycated serum protein and esophageal metrics in diabetic GERD patients.Open medicine (Warsaw, Poland) · 2026Article
- Molecular and Functional Recovery of Esophageal Barrier Integrity After Laparoscopic Anti-reflux Surgery.Digestive diseases and sciences · 2025Article
- Morphological and Redox/Glycative Alterations in the PCOS Oviducts: Modulating Effects of Carnitines in PCOS Mice.Biology · 2024Article
- Eosinophilic esophagitis: Immune mechanisms and therapeutic targets.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Application of electron microscopy in gastroenterology.World journal of gastrointestinal pathophysiology · 2022Article
- Nitric oxide and inducible nitric oxide synthase levels in EE and NERD patients.Gastroenterology and hepatology from bed to bench · 2022Article
- Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: History, Mechanisms, Efficacy, and Future Directions.Journal of asthma and allergy · 2022Review
- theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions.Frontiers in pharmacology · 2021Review
- Distal Esophageal Impedance Measured by High-resolution Esophageal Manometry With Impedance Suggests the Presence of Barrett's Esophagus.Journal of neurogastroenterology and motility · 2020Article
- Gastroesophageal reflux in cystic fibrosis across the age spectrum.Translational gastroenterology and hepatology · 2019Article
- Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2018Article
- The Relationship of the Post-reflux Swallow-induced Peristaltic Wave Index and Esophageal Baseline Impedance with Gastroesophageal Reflux Disease Symptoms.Journal of neurogastroenterology and motility · 2017Article
- Esophageal Impedance Monitoring: Clinical Pearls and Pitfalls.The American journal of gastroenterology · 2016Review
- Influence of reflux and central obesity on intercellular space diameter of esophageal squamous epithelium.United European gastroenterology journal · 2016Article
- Bile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016Article
- A bama minipig model of laryngopharyngeal reflux and the change of laryngopharyngeal mucosal ultrastructure.Journal of neurogastroenterology and motility · 2015Article
- Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis.Mucosal immunology · 2014Article
- Evidence for bladder urothelial pathophysiology in functional bladder disorders.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) is typically heralded by the substernal burning pain of heartburn. On endoscopic examination, about one third of GERD subjects with heartburn have erosive disease, and the remainder have nonerosive reflux disease (NERD). Unlike patients with erosive disease, those with NERD (approximately 50%) often do not respond to therapy with proton pump inhibitors (PPIs), raising the question of whether they have NERD and, if they do, whether the cause of their symptoms is similar to those who respond to PPIs. Recently, biopsies established that subjects with heartburn and PPI-responsive NERD, like those with erosive esophagitis, have lesions within the esophageal epithelium known as dilated intercellular space (DIS). In this article, we discuss the physicochemical basis for DIS in acid-injured esophageal epithelium and its significance in GERD. Although DIS is not pathognomic of GERD, it is a marker of a break in the epithelial (junctional) barrier reflecting an increase in paracellular permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.