ArticleCritical care (London, England)2009
Ventilator-associated pneumonia in patients undergoing major heart surgery: an incidence study in Europe.
Article in Critical care (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- A model-based cost-effectiveness analysis of Patient Blood Management.Blood transfusion = Trasfusione del sangue · 2019Pooled it
- Development and validation of a risk prediction model for postoperative pneumonia in adult patients undergoing Stanford type A acute aortic dissection surgery: a case control study.Journal of cardiothoracic surgery · 2022Trial
- Impact of four sequential measures on the prevention of ventilator-associated pneumonia in cardiac surgery patients.Critical care (London, England) · 2014Trial
- Pre-emptive broad-spectrum treatment for ventilator-associated pneumonia in high-risk patients.Intensive care medicine · 2013Trial
- Inadequate cytoplasmatic calcium signals in alveolar macrophages after cardiac surgery.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Trial
- Incidence, patterns, and factors associated with postoperative pulmonary complications in an ERAS cardiac surgery program: a 500-patient cohort study.Journal of anesthesia, analgesia and critical care · 2026Article
- Prevalence of Healthcare-Associated Infections in Patients with Cardiovascular Diseases: A Literature Review.Journal of clinical medicine · 2025Review
- Review
- The predictive role of modified stress hyperglycemia rate in predicting early pneumonia after isolated coronary bypass surgery in patients with diabetes mellitus.Biomolecules & biomedicine · 2025Article
- Prevalence and risk factors for ventilator-associated pneumonia after cardiac surgery: a systematic review and meta-analysis.Journal of thoracic disease · 2024Article
- Early extubation after elective surgical aortic valve replacement during the COVID-19 pandemic.Journal of cardiothoracic surgery · 2024Article
- Rebound Inverts theAntibiotics (Basel, Switzerland) · 2024Article
- Identification of a marker of infection in the breath using a porcine pneumonia model.JTCVS open · 2023Article
- Identification of risk factors for infection after mitral valve surgery through machine learning approaches.Frontiers in cardiovascular medicine · 2023Article
- Risk Factors for Post-cardiac Surgery Infections.Cureus · 2022Article
- Ventilator-Associated Pneumonia, Multidrug-Resistant Bacteremia and Infection Control Interventions in an Intensive Care Unit: Analysis of Six-Year Time-Series Data.Antibiotics (Basel, Switzerland) · 2022Article
- Evaluation of the significance of interleukin-6 in the diagnosis of postoperative pneumonia: a prospective study.BMC cardiovascular disorders · 2022Observational
- Study of risk factors for healthcare-associated infections in acute cardiac patients using categorical principal component analysis (CATPCA).Scientific reports · 2022Article
- Pneumonia After Cardiovascular Surgery: Incidence, Risk Factors and Interventions.Frontiers in cardiovascular medicine · 2022Review
- Risk factors for postoperative pneumonia after cardiac surgery: a prediction model.Journal of thoracic disease · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients undergoing major heart surgery (MHS) represent a special subpopulation at risk for nosocomial infections. Postoperative infection is the main non-cardiac complication after MHS and has been clearly related to increased morbidity, use of hospital resources and mortality. Our aim was to determine the incidence, aetiology, risk factors and outcome of ventilator-associated pneumonia (VAP) in patients who have undergone MHS in Europe.
methodsOur study was a prospective study of patients undergoing MHS in Europe who developed suspicion of VAP. During a one-month period, participating units submitted a protocol of all patients admitted to their units who had undergone MHS.
resultsOverall, 25 hospitals in eight different European countries participated in the study. The number of patients intervened for MHS was 986. Fifteen patients were excluded because of protocol violations. One or more nosocomial infections were detected in 43 (4.4%) patients. VAP was the most frequent nosocomial infection (2.1%; 13.9 episodes per 1000 days of mechanical ventilation). The microorganisms responsible for VAP in this study were: Enterobacteriaceae (45%), Pseudomonas aeruginosa (20%), methicillin-resistant Staphylococcus aureus (10%) and a range of other microorganisms. We identified the following significant independent risk factors for VAP: ascending aorta surgery (odds ratio (OR) = 6.22; 95% confidence interval (CI) = 1.69 to 22.89), number of blood units transfused (OR = 1.08 per unit transfused; 95% CI = 1.04 to 1.13) and need for re-intervention (OR = 6.65; 95% CI = 2.10 to 21.01). The median length of stay in the intensive care unit was significantly longer (P < 0.001) in patients with VAP than in patients without VAP (23 days versus 2 days). Death was significantly more frequent (P < 0.001) in patients with VAP (35% versus 2.3%).
conclusionsPatients undergoing aortic surgery and those with complicated post-intervention courses, requiring multiple transfusions or re-intervention, constitute a high-risk group probably requiring more active preventive measures.
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