ArticleThe journal of physical chemistry. B2009
1H photo-CIDNP enhancements in heteronuclear correlation NMR spectroscopy.
Article in The journal of physical chemistry. B, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Nuclear-Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra-High Field.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2026Article
- Dynamic nuclear polarization and chemically induced hyperpolarization: Progress, mechanisms, and opportunities.Magnetic resonance letters · 2025Review
- Multinuclear 1D and 2D NMR withNature communications · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Improved sensitivity of laser-enhancedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- Effect of heavy atoms on photochemically induced dynamic nuclear polarization in liquids.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2018Article
- Sensitivity enhancement in solution NMR: emerging ideas and new frontiers.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2014Review
- A novel tri-enzyme system in combination with laser-driven NMR enables efficient nuclear polarization of biomolecules in solution.The journal of physical chemistry. B · 2013Article
- 1H-Detected 13C photo-CIDNP as a sensitivity enhancement tool in solution NMR.Journal of the American Chemical Society · 2011Article
- EPIC- and CHANCE-HSQC: two 15N-photo-CIDNP-enhanced pulse sequences for the sensitive detection of solvent-exposed tryptophan.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Photochemically induced dynamic nuclear polarization (photo-CIDNP) is usually employed as a probe of solvent exposure in biomolecular NMR. The potential of the photo-CIDNP effect for sensitivity enhancement, however, remains poorly explored. Here, we introduce (1)H-photo-CIDNP in heteronuclear correlation spectroscopy at low laser irradiation power (1 W), and compare the sensitivity of various (1)H-photo-CIDNP-enhanced- (HPE) (1)H-(15)N heteronuclear correlation pulse sequences, including HSQC, HMQC, and SOFAST-HMQC, in terms of their ability to detect the Trp indole H(epsilon1) resonance. Both Trp and the Trp-containing protein apoHmpH were analyzed using flavin mononucleotide as photosensitizer in aqueous solutions either containing or lacking urea. We find that (1)H-(15)N photo-CIDNP-SOFAST-HMQC, denoted here as HPE-SOFAST-HMQC, yields a 2-fold higher signal-to-noise per unit time than the parent SOFAST-HMQC, for the solvent-exposed Trp of urea-unfolded apoHmpH. Thus, HPE-SOFAST-HMQC is the most sensitive heteronuclear correlation pulse sequence for the detection of solvent-exposed Trp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.