ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2009
4-Aminopyridine improves spatial memory in a murine model of HIV-1 encephalitis.
Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- cART Exacerbates Cocaine-Induced Cortical Neuron Hyperactivity in Non-Transgenic but Not HIV-1 Transgenic Rats.Membranes · 2026Article
- Scaling Synapses in the Presence of HIV.Neurochemical research · 2019Review
- N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive Disorders.Journal of medicinal chemistry · 2017Article
- Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation.Journal of cell death · 2015Article
- Plasma gelsolin protects HIV-1 gp120-induced neuronal injury via voltage-gated K+ channel Kv2.1.Molecular and cellular neurosciences · 2013Article
- HIV-1 Tat protein increases microglial outward K(+) current and resultant neurotoxic activity.PloS one · 2013Article
- Curcumin protects microglia and primary rat cortical neurons against HIV-1 gp120-mediated inflammation and apoptosis.PloS one · 2013Article
- Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women.Journal of neurovirology · 2012Article
- Involvement of microglia activation in the lead induced long-term potentiation impairment.PloS one · 2012Article
- Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage.Journal of toxicology · 2012Article
- HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents.PloS one · 2011Article
- HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells.PloS one · 2011Article
- Involvement of the 4-aminopyridine-sensitive transient A-type K+ current in macrophage-induced neuronal injury.The European journal of neuroscience · 2010Article
- NanoART, neuroAIDS and CNS drug delivery.Nanomedicine (London, England) · 2009Review
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4 authors at 1 institution in 1 country.
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Abstract
HIV-1-associated neurocognitive disorders (HAND) remains a significant source of morbidity in the era of wide spread use of highly active antiretroviral therapy. Disease is precipitated by low levels of viral growth and glial immune activation within the central nervous system. Blood borne macrophage and microglia affect a proinflammatory response and release viral proteins that affects neuronal viability and leads to death of nerve cells. Increasing evidence supports the notion that HAND is functional channelopathy, but proof of this concept remains incomplete. Based on their role in learning and memory processes, we now posit that voltage-gated potassium (K(v)) channels could be a functional substrate for disease. This was tested in the severe combined immunodeficient (SCID) mouse model of HIV-1 encephalitis (HIVE) by examining whether the K(v) channel blocker, 4-aminopyridine (4-AP), could affect behavioral, electrophysiological, and morphological measures of learning and memory. HIVE SCID mice showed impaired spatial memory in radial arm water maze tests. Electrophysiology studies revealed a reduction of long-term potentiation (LTP) in the CA1 region of the hippocampus. Importantly, systemic administration of 4-AP blocked HIV-1-associated reduction of LTP and improved animal performance in the radial arm water maze. These results support the importance of K(v) channel dysfunction in disease but, more importantly, provide a potential target for adjunctive therapies for HAND.
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