ArticlePloS one2009
The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
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Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis.Molecular psychiatry · 2015Pooled it
- The molecular genetic architecture of self-employment.PloS one · 2013Pooled it
- Oxytocin receptor gene variations and socio-emotional effects of MDMA: A pooled analysis of controlled studies in healthy subjects.PloS one · 2018Trial
- Oxytocin promotes altruistic punishment.Social cognitive and affective neuroscience · 2017Trial
- Oxytocin tempers calculated greed but not impulsive defense in predator-prey contests.Social cognitive and affective neuroscience · 2015Trial
- Oxytocin promotes human ethnocentrism.Proceedings of the National Academy of Sciences of the United States of America · 2011Trial
- Genetic variations as predictors of dispositional and dyadic empathy-a couple study.Scientific reports · 2024Article
- OXTR polymorphisms associated with severity and treatment responses of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
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- Association between arginine vasopressin receptor 1A (Proceedings. Biological sciences · 2023Article
- The interaction engine: cuteness selection and the evolution of the interactional base for language.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Altered Cerebral Curvature in Preterm Infants Is Associated with the Common Genetic Variation Related to Autism Spectrum Disorder and Lipid Metabolism.Journal of clinical medicine · 2022Article
- The Current Status of Drug Discovery for the Oxytocin Receptor.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Empathy, Theory of Mind, and Prosocial Behaviors in Autistic Children.Frontiers in psychiatry · 2022Article
- Neurobiological Correlates of Fatherhood During the Postpartum Period: A Scoping Review.Frontiers in psychology · 2022Article
- Altruism and Phenoptosis as Programs Supported by Evolution.Biochemistry. Biokhimiia · 2021Article
- The oxytocin system and early-life experience-dependent plastic changes.Journal of neuroendocrinology · 2021Review
- An interaction between early threat exposure and the oxytocin receptor in females: Disorder-specific versus general risk for psychopathology and social-emotional mediators.Development and psychopathology · 2021Article
- A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
29 more citing papers are in PubMed but not listed here.
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11 authors.
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Abstract
backgroundEconomic games observe social decision making in the laboratory that involves real money payoffs. Previously we have shown that allocation of funds in the Dictator Game (DG), a paradigm that illustrates costly altruistic behavior, is partially determined by promoter-region repeat region variants in the arginine vasopressin 1a receptor gene (AVPR1a). In the current investigation, the gene encoding the related oxytocin receptor (OXTR) was tested for association with the DG and a related paradigm, the Social Values Orientation (SVO) task. METHODOLOGY/PRINCIPAL
findingsAssociation (101 male and 102 female students) using a robust-family based test between 15 single tagging SNPs (htSNPs) across the OXTR was demonstrated with both the DG and SVO. Three htSNPs across the gene region showed significant association with both of the two games. The most significant association was observed with rs1042778 (p = 0.001). Haplotype analysis also showed significant associations for both DG and SVO. Following permutation test adjustment, significance was observed for 2-5 locus haplotypes (p<0.05). A second sample of 98 female subjects was subsequently and independently recruited to play the dictator game and was genotyped for the three significant SNPs found in the first sample. The rs1042778 SNP was shown to be significant for the second sample as well (p = 0.004, Fisher's exact test).
conclusionsThe demonstration that genetic polymorphisms for the OXTR are associated with human prosocial decision making converges with a large body of animal research showing that oxytocin is an important social hormone across vertebrates including Homo sapiens. Individual differences in prosocial behavior have been shown by twin studies to have a substantial genetic basis and the current investigation demonstrates that common variants in the oxytocin receptor gene, an important element of mammalian social circuitry, underlie such individual differences.
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