ArticlePloS one2009
Musical aptitude is associated with AVPR1A-haplotypes.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 125 citations in OpenAlex.
- Associations of the AVPR1A RS1 Microsatellite Locus with the Level of Hormones of the Anterior Pituitary Gland and Personality Traits.Biochemical genetics · 2025Article
- Attention, musicality, and familiarity shape cortical speech tracking at the musical cocktail party.Brain and language · 2025Article
- Rhythmic Roots: The Adaptive Functions of Vocal Isochrony and Its Role in Human Music and Language Evolution.Psihologijske teme = Psychological themes = Psychological topics · 2025Article
- Biological principles for music and mental health.Translational psychiatry · 2023Review
- Moderate associations betweenHeliyon · 2023Article
- Testosterone, oxytocin and co-operation: A hypothesis for the origin and function of music.Frontiers in psychology · 2023Article
- Ventral tegmental area dopaminergic action in music therapy for post-traumatic stress disorder: A literature review.Frontiers in psychology · 2022Review
- Auditory affective processing, musicality, and the development of misophonic reactions.Frontiers in neuroscience · 2022Review
- Review
- Human Genomics and the Biocultural Origin of Music.International journal of molecular sciences · 2021Review
- How far musicality and perfect pitch are derived from genetic factors?Journal of applied genetics · 2020Review
- Links Between the Neurobiology of Oxytocin and Human Musicality.Frontiers in human neuroscience · 2020Review
- Long-Term Musical Training Alters Auditory Cortical Activity to the Frequency Change.Frontiers in human neuroscience · 2020Article
- Inherent auditory skills rather than formal music training shape the neural encoding of speech.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Behavioral and subcortical signatures of musical expertise in Mandarin Chinese speakers.PloS one · 2018Article
- Hypothesizing Music Intervention Enhances Brain Functional Connectivity Involving Dopaminergic Recruitment: Common Neuro-correlates to Abusable Drugs.Molecular neurobiology · 2017Article
- Visual-spatial sequence learning and memory in trained musicians.Psychology of music · 2017Article
- The Paradox of Isochrony in the Evolution of Human Rhythm.Frontiers in psychology · 2017Article
- Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior.Frontiers in neuroendocrinology · 2016Review
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artistic creativity forms the basis of music culture and music industry. Composing, improvising and arranging music are complex creative functions of the human brain, which biological value remains unknown. We hypothesized that practicing music is social communication that needs musical aptitude and even creativity in music. In order to understand the neurobiological basis of music in human evolution and communication we analyzed polymorphisms of the arginine vasopressin receptor 1A (AVPR1A), serotonin transporter (SLC6A4), catecol-O-methyltranferase (COMT), dopamin receptor D2 (DRD2) and tyrosine hydroxylase 1 (TPH1), genes associated with social bonding and cognitive functions in 19 Finnish families (n = 343 members) with professional musicians and/or active amateurs. All family members were tested for musical aptitude using the auditory structuring ability test (Karma Music test; KMT) and Carl Seashores tests for pitch (SP) and for time (ST). Data on creativity in music (composing, improvising and/or arranging music) was surveyed using a web-based questionnaire. Here we show for the first time that creative functions in music have a strong genetic component (h(2) = .84; composing h(2) = .40; arranging h(2) = .46; improvising h(2) = .62) in Finnish multigenerational families. We also show that high music test scores are significantly associated with creative functions in music (p<.0001). We discovered an overall haplotype association with AVPR1A gene (markers RS1 and RS3) and KMT (p = 0.0008; corrected p = 0.00002), SP (p = 0.0261; corrected p = 0.0072) and combined music test scores (COMB) (p = 0.0056; corrected p = 0.0006). AVPR1A haplotype AVR+RS1 further suggested a positive association with ST (p = 0.0038; corrected p = 0.00184) and COMB (p = 0.0083; corrected p = 0.0040) using haplotype-based association test HBAT. The results suggest that the neurobiology of music perception and production is likely to be related to the pathways affecting intrinsic attachment behavior.
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