Evidence map›Paper›PMID 19461428›Full record

Trial reportObstetrics and gynecology2009

Risk factors for postpartum hemorrhage in vaginal deliveries in a Latin-American population.

Claudio G Sosa, Fernando Althabe, José M Belizán, Pierre Buekens

2 registry-linked trialsOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Obstetrics and gynecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02411916 nacompletednot on this mapstarted 2012, after this paper: background citation

Effect of Adjunctive Misoprostol on Blood Loss at Vaginal Delivery

TypeinterventionalSponsorNew York City Health and Hospitals CorporationRan2012 to 2019Enrolled143ConditionsPostpartum HemorrhageArmsmisoprostol
NCT05448456 phase4completednot on this mapstarted 2022, after this paper: background citation

Use of Tranexamic Acid After Vaginal Delivery with Episiotomy a RCT Placebo Control Trail

TypeinterventionalSponsorAssuta Ashdod HospitalRan2022 to 2024Enrolled150ConditionsEpisiotomy Wound, Anemia, Early Postpartum Hemorrhage, HemoglobinArmsTranexamic acid, Placebo
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 195 citations in OpenAlex.

  1. Fetal Macrosomia and Postpartum Hemorrhage in Latin American and Caribbean Region: Systematic Review and Meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023
    Pooled it
  2. Pooled it
  3. Prostaglandins for management of retained placenta.The Cochrane database of systematic reviews · 2014
    Pooled it
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  17. Iron Deficiency Anaemia and Atonic Postpartum Haemorrhage Following Labour.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Article
  18. The Pan African medical journal · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Claudio G SosaFrom the Perinatal Research Unit, School of Medicine, University of Uruguay, Montevideo, Uruguay; the Institute of Clinical Effectiveness and Health Policy, Buenos Aires, Argentina; and the School of Public Health and Tropical Medicine, Tulane University, New Orleans. Louisiana.
Fernando Althabe
José M Belizán
Pierre Buekens
Instituto de Efectividad Clínica y Sanitaria · ARUniversidad de Montevideo · UY

Funding

Evidence-Based Global Health Interventions for Mothers and Children, ArgentinaU01HD040477 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BUEKENS, PIERRE · 2001 to 2013
$5.6M
Latin American Perinatal Health Training ProgramD43TW005492 · FIC · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BUEKENS, PIERRE · 2001 to 2005
$820k
Risk factors for medically indicated preterm birth in a Latin American populationR01TW007600 · FIC · FACULTAD DE MEDICINA · PI SOSA, CLAUDIO GERARDO · 2006 to 2010
$258k
FIC NIH HHS D43 TW005492FIC NIH HHS R01 TW007600FIC NIH HHS TW05492NICHD NIH HHS U01 HD040477NICHD NIH HHS U01HD040477
6 · The paper itself

Abstract

objectiveTo identify risk factors for immediate postpartum hemorrhage after vaginal delivery in a South American population.

methodsThis was a prospective cohort study including all vaginal births (N=11,323) between October and December 2003 and October and December 2005 from 24 maternity units in two South American countries (Argentina and Uruguay). Blood loss was measured in all births using a calibrated receptacle. Moderate postpartum hemorrhage and severe postpartum hemorrhage were defined as blood loss of at least 500 mL and at least 1,000 mL, respectively.

resultsModerate and severe postpartum hemorrhage occurred in 10.8% and 1.9% of deliveries, respectively. The risk factors more strongly associated and the incidence of moderate postpartum hemorrhage in women with each of these factors were: retained placenta (33.3%) (adjusted odds ratio [OR] 6.02, 95% confidence interval [CI] 3.50-10.36), multiple pregnancy (20.9%) (adjusted OR 4.67, CI 2.41-9.05), macrosomia (18.6%) (adjusted OR 2.36, CI 1.93-2.88), episiotomy (16.2%) (adjusted OR 1.70, CI 1.15-2.50), and need for perineal suture (15.0%) (adjusted OR 1.66, CI 1.11-2.49). Active management of the third stage of labor, multiparity, and low birth weight were found to be protective factors. Severe postpartum hemorrhage was associated with retained placenta (17.1%) (adjusted OR 16.04, CI 7.15-35.99), multiple pregnancy (4.7%) (adjusted OR 4.34, CI 1.46-12.87), macrosomia (4.9%) (adjusted OR 3.48, CI 2.27-5.36), induced labor (3.5%) (adjusted OR 2.00, CI 1.30-3.09), and need for perineal suture (2.5%) (adjusted OR 2.50, CI 1.87-3.36).

conclusionMany of the risk factors for immediate postpartum hemorrhage in this South American population are related to complications of the second and third stage of labor. LEVEL OF EVIDENCE: II.

Indexed as

AdultCohort StudiesDelivery, ObstetricEpisiotomyFemaleFetal MacrosomiaHumansLabor Stage, SecondLabor Stage, ThirdLatin AmericaPlacenta, RetainedPostpartum HemorrhagePregnancyPregnancy, MultipleProspective StudiesRisk Factors

Identifiers

PMID19461428
PMCPMC2730945
OpenAlexW2018899833

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.