Evidence map›Paper›PMID 19461057›Full record

Trial reportAJNR. American journal of neuroradiology2009

Difficult aneurysms for endovascular treatment: overwide or undertall?

W Brinjikji, H J Cloft, D F Kallmes

2 registry-linked trialsAbstract readClinical Trial
In one paragraph

Trial report in AJNR. American journal of neuroradiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06761365 narecruitingnot on this mapstarted 2024, after this paper: background citation

A single-arm, open label, multi-center early feasibility study of the luseed aneurysm embolization system in individuals with upruptured intracranial aneurysms

TypeinterventionalSponsorLuSeed Vascular LTD.Ran2024 to 2027Enrolled30ConditionsAneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular AneurysmArmsLuSeed Aneurysm Embolization System
NCT07259018 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Single-arm, Open Label, Single-center Early Feasibility Study of the LuSeed Aneurysm Embolization System in Individuals With Unruptured Intracranial Aneurysms.

TypeinterventionalSponsorLuSeed Vascular LTD.Ran2025 to 2028Enrolled10ConditionsAneurysm Cerebral, Bifurcation, Unruptured Intracranial Aneurysm, Saccular AneurysmArmsLuSeed Aneurysm Embolization System
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Safety of stent-assisted coiling for the treatment of wide-necked ruptured aneurysm: A systematic literature review and meta-analysis of prevalence.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020
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  14. A new era in the treatment of wide necked bifurcation aneurysms: Intrasaccular flow disruption.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

W BrinjikjiMayo Medical School, 200 SW First Street, Rochester, MN 55905, USA.
H J Cloft
D F Kallmes

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAneurysm geometry has been shown to predict the need for adjunctive techniques in the endovascular treatment of intracranial aneurysms. We conducted a systematic retrospective study examining which thresholds of dome-to-neck ratio, maximum neck width, and aspect ratio of intracranial aneurysms best predict the need for adjunctive techniques in endovascular management. MATERIALS AND

methodsOne hundred seventy-five consecutive patients who were selected for attempted embolization of 185 intracranial aneurysms were included in this study. Aneurysm dome-to-neck ratio (maximum dome width/maximum neck width), maximum neck width, and aspect ratio (dome height/maximum neck width) were measured on 2D digital subtraction angiography. Statistical analysis was conducted to determine which thresholds of dome-to-neck ratio, maximum neck width, and aspect ratio were most predictive of the need for adjunctive devices in endovascular management of these aneurysms.

resultsWe demonstrated that 75% of aneurysms with dome-to-neck ratios >1.6 (P < .0001), 75% of aneurysms with aspect ratios >1.6 (P < .0001), and 70% of aneurysms with neck diameters <4.0 mm (P < .0001) did not need adjunctive techniques in their management. Adjunctive techniques were essential to treatment of 80% of aneurysms with dome-to-neck ratios <1.2 (P = .02) and 89% of aneurysms with aspect ratios <1.2 (P < .0001). Multivariate logistic regression analysis demonstrated that aspect ratio was the best predictor of the need for an adjunctive device (P = .0004).

conclusionsAneurysms with aspect and dome-to-neck ratios >1.6 usually did not require adjunctive techniques. Aneurysms with aspect and dome-to-neck ratios <1.2 almost always required adjunctive techniques. In this single-center series, aspect ratio was the independent predictor of the need for adjunctive techniques in the endovascular management of intracranial aneurysms.

Indexed as

Angiography, Digital SubtractionBlood Vessel ProsthesisEmbolization, TherapeuticFemaleHumansIncidenceIntracranial AneurysmMaleMiddle AgedMinnesotaPatient SelectionPrognosisRetrospective StudiesRisk AssessmentRisk FactorsTreatment Outcome

Identifiers

PMID19461057
PMCPMC7051599

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.