ArticleSchizophrenia bulletin2011
Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study.
Article in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 170 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
170 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Unravelling Distress in Psychotic-Like Experiences: A Systematic Review of Non-Clinical Populations.Early intervention in psychiatry · 2026Pooled it
- Mindfulness and psychotic-like experiences in nonclinical populations: a systematic review and two meta-analyses.Psychological medicine · 2026Pooled it
- Cognitive functioning in people with psychotic experiences: a systematic review and meta-analysis study.Molecular psychiatry · 2025Pooled it
- Hallucinations in Children and Adolescents: An Updated Review and Practical Recommendations for Clinicians.Schizophrenia bulletin · 2019Pooled it
- A systematic review of genome-wide research on psychotic experiences and negative symptom traits: new revelations and implications for psychiatry.Human molecular genetics · 2018Pooled it
- Efficacy of a transdiagnostic, prevention-focused program for at-risk young adults: a waitlist-controlled trial.Psychological medicine · 2023Trial
- Treating Sleep Problems in Young People at Ultra-High Risk of Psychosis: A Feasibility Case Series.Behavioural and cognitive psychotherapy · 2018Trial
- The association between negative symptoms, psychotic experiences and later schizophrenia: a population-based longitudinal study.PloS one · 2015Trial
- A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness.BMC psychiatry · 2014Trial
- Subclinical delusional thinking predicts lateral temporal cortex responses during social reflection.Social cognitive and affective neuroscience · 2014Trial
- Cognitive behavioral therapy for subjects at ultrahigh risk for developing psychosis: a randomized controlled clinical trial.Schizophrenia bulletin · 2012Trial
- Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial.BMJ (Clinical research ed.) · 2012Trial
- Serum 25-hydroxyvitamin D3 and D2 and non-clinical psychotic experiences in childhood.PloS one · 2012Trial
- Hippocampal volume and persistent distressing psychotic-like experiences across early adolescence: the moderating role of physical activity.Schizophrenia research · 2026Article
- Do Psychological Interventions Reduce Paranoia in Adolescents? A Systematic Review.Clinical child and family psychology review · 2026Review
- Distinct Connectivity Signatures of Hallucinatory Experiences and Neuromelanin Signal in Community-Dwelling Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Describing Psychotic Experiences Through Online Psychosis Screens: A Content Analysis.International journal of methods in psychiatric research · 2026Article
- The Relationship Between Trauma Exposure and Nonclinical Psychosis: A Systematic Review and Meta-Analysis.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026Article
- The Effect of Smoking Cigarettes on the Progression of Psychotic Experiences to Psychotic Disorder: Evidence From a 6-Year Follow-Up Study.The International journal of social psychiatry · 2026Article
- Neuroimaging Summary Scores Predict Trajectories of Psychotic-Like Experiences in Youth.medRxiv : the preprint server for health sciences · 2026Article
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the hypothesis that developmental expression of psychometric risk in the form of subclinical psychotic experiences in the general population is usually transitory but in some instances may become abnormally persistent and progress to a clinical psychotic state. A prospective cohort study was conducted in a general population sample of 845 adolescents, aged 14-17 years, in Munich, Germany (Early Developmental Stages of Psychopathology Study). Expression of psychosis was assessed 4 times (T0-T3) over a period of 8.4 years. Transition from subclinical psychosis at T0-T2 to clinical psychosis in terms of impairment at T3 was examined as a function of the level of prior persistence of subclinical psychosis (present never, once, twice, or thrice). The more the subclinical psychosis persisted over the period T0-T2, the greater the risk of transition to clinical psychosis at T3 in a dose-response fashion (subclinical psychosis expression once over T0-T2: odds ratio [OR] = 1.5 [95% confidence interval {CI} = 0.6-3.7], posttest probability [PP] = 5%; twice: OR = 5.0 [95% CI = 1.6-15.9], PP = 16%; at all 3 measurements: OR = 9.9 [95% CI = 2.5-39.8], PP = 27%). Of all clinical psychosis at T3, more than a third (38.3%) was preceded by subclinical psychotic experiences at least once and a fifth (19.6%) at least twice. Consequently, a significant proportion of psychotic disorder may be conceptualized as the rare poor outcome of a common developmental phenotype characterized by persistence of psychometrically detectable subclinical psychotic experiences. This may be summarized descriptively as a psychosis proneness-persistence-impairment model of psychotic disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.