ArticleRNA (New York, N.Y.)2009
Dicer independent small RNAs associate with telomeric heterochromatin.
Article in RNA (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Subtle-seq reveals frequent ageing-associated chromosome fragmentation on nucleosome core DNA.Nucleic acids research · 2026Article
- The NSL complex is required for piRNA production from telomeric clusters.Life science alliance · 2023Article
- tiRNAs: Insights into Their Biogenesis, Functions, and Future Applications in Livestock Research.Non-coding RNA · 2022Review
- Genetic and Epigenetic Inheritance at Telomeres.Epigenomes · 2022Review
- Noncoding RNA Roles in Pharmacogenomic Responses to Aspirin: New Molecular Mechanisms for an Old Drug.BioMed research international · 2021Review
- Endogenization and excision of human herpesvirus 6 in human genomes.PLoS genetics · 2020Article
- The epigenetic regulation of centromeres and telomeres in plants and animals.Comparative cytogenetics · 2020Review
- A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs.International journal of molecular sciences · 2020Review
- Telomeric small RNAs in the genusRNA (New York, N.Y.) · 2019Article
- LncRNAs regulating stemness in aging.Aging cell · 2019Review
- BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin.PloS one · 2019Article
- Roles for Non-coding RNAs in Spatial Genome Organization.Frontiers in cell and developmental biology · 2019Review
- Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline.Epigenetics & chromatin · 2018Article
- From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond.Chemical reviews · 2018Review
- Shortcuts to a functional adipose tissue: The role of small non-coding RNAs.Redox biology · 2017Review
- Telomeric repeat silencing in germ cells is essential for early development in Drosophila.Nucleic acids research · 2015Article
- Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.Scientific reports · 2015Article
- A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs.Neurotoxicity research · 2015Review
- Non-Coding RNA: Sequence-Specific Guide for Chromatin Modification and DNA Damage Signaling.Frontiers in genetics · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Small RNAs play important roles in the establishment and maintenance of heterochromatin structures. We show the presence of telomere specific small RNAs (tel-sRNAs) in mouse embryonic stem cells that are approximately 24 nucleotides in length, Dicer-independent, and 2'-O-methylated at the 3' terminus. The tel-sRNAs are asymmetric with specificity toward telomere G-rich strand, and evolutionarily conserved from protozoan to mammalian cells. Furthermore, tel-sRNAs are up-regulated in cells that carry null mutation of H3K4 methyltransferase MLL (Mll((-/-))) and down-regulated in cells that carry null mutations of histone H3K9 methyltransferase SUV39H (Suv39h1/h2((-/-))), suggesting that they are subject to epigenetic regulation. These results support that tel-sRNAs are heterochromatin associated pi-like small RNAs.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.