ArticleBMC infectious diseases2009
Laboratory-based evaluation of legionellosis epidemiology in Ontario, Canada, 1978 to 2006.
Article in BMC infectious diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The etiology of community-acquired pneumonia among children under 5 years of age in mainland China, 2001-2015: A systematic review.Human vaccines & immunotherapeutics · 2017Pooled it
- The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Guideline
- Review
- Diagnostic Study to Assess the Performance of a New UrinaryInternational journal of environmental research and public health · 2022Article
- Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999-2017.Scientific reports · 2021Observational
- Development of a Fluorescent Tool for StudyingMicroorganisms · 2021Article
- Legionellosis in Japan: A Self-inflicted Wound?Internal medicine (Tokyo, Japan) · 2021Article
- Sexual dimorphism in bacterial infections.Biology of sex differences · 2018Review
- Unusual Legionnaires' outbreak in cool, dry Western Canada: an investigation using genomic epidemiology.Epidemiology and infection · 2017Article
- Evaluation and Comparison of Multiple Test Methods, Including Real-time PCR, for Legionella Detection in Clinical Specimens.Frontiers in public health · 2016Article
- Dendrimers and Polyamino-Phenolic Ligands: Activity of New Molecules Against Legionella pneumophila Biofilms.Frontiers in microbiology · 2016Article
- Current and emerging Legionella diagnostics for laboratory and outbreak investigations.Clinical microbiology reviews · 2015Review
- Comparative Genomics Reveal That Host-Innate Immune Responses Influence the Clinical Prevalence of Legionella pneumophila Serogroups.PloS one · 2013Article
- Community-acquired Legionella pneumophila pneumonia: a single-center experience with 214 hospitalized sporadic cases over 15 years.Medicine · 2013Article
- Distribution of Legionella species from environmental water sources of public facilities and genetic diversity of L. pneumophila serogroup 1 in South Korea.Applied and environmental microbiology · 2010Article
- New endemic Legionella pneumophila serogroup I clones, Ontario, Canada.Emerging infectious diseases · 2010Article
- Legionella pneumophila monoclonal antibody subgroups and DNA sequence types isolated in Canada between 1981 and 2009: Laboratory Component of National Surveillance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLegionellosis is a common cause of severe community acquired pneumonia and respiratory disease outbreaks. The Ontario Public Health Laboratory (OPHL) has conducted most testing for Legionella species in the Canadian province of Ontario since 1978, and represents a multi-decade repository of population-based data on legionellosis epidemiology. We sought to provide a laboratory-based review of the epidemiology of legionellosis in Ontario over the past 3 decades, with a focus on changing rates of disease and species associated with legionellosis during that time period.
methodsWe analyzed cases that were submitted and tested positive for legionellosis from 1978 to 2006 using Poisson regression models incorporating temporal, spatial, and demographic covariates. Predictors of infection with culture-confirmed L. pneumophila serogroup 1 (LP1) were evaluated with logistic regression models.
results1,401 cases of legionellosis tested positive from 1978 to 2006. As in other studies, we found a late summer to early autumn seasonality in disease occurrence with disease risk increasing with age and in males. In contrast to other studies, we found a decreasing trend in cases in the recent decade (IRR 0.93, 95% CI 0.91 to 0.95, P-value = 0.001); only 66% of culture-confirmed isolates were found to be LP1.
conclusionDespite similarities with disease epidemiology in other regions, legionellosis appears to have declined in the past decade in Ontario, in contrast to trends observed in the United States and parts of Europe. Furthermore, a different range of Legionella species is responsible for illness, suggesting a distinctive legionellosis epidemiology in this North American region.
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