ArticleMolecular microbiology2009
Borrelia burgdorferi bb0426 encodes a 2'-deoxyribosyltransferase that plays a central role in purine salvage.
Article in Molecular microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Effects of Inosine-5'-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors onMicroorganisms · 2024Article
- Riboflavin salvage by Borrelia burgdorferi supports carbon metabolism and is essential for survival in the tick vector.Molecular microbiology · 2022Article
- A NovelMicrobiology spectrum · 2022Article
- Biochemical and structural studies of two tetrameric nucleoside 2'-deoxyribosyltransferases from psychrophilic and mesophilic bacteria: Insights into cold-adaptation.International journal of biological macromolecules · 2021Article
- Molecular Basis of NDT-Mediated Activation of Nucleoside-Based Prodrugs and Application in Suicide Gene Therapy.Biomolecules · 2021Article
- Unconventional Approaches to Direct Detection of Borreliosis and Other Tick Borne Illnesses: A Path Forward.Journal of cellular immunology · 2021Article
- Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family.Infection and immunity · 2020Article
- Nitric oxide disrupts bacterial cytokinesis by poisoning purine metabolism.Science advances · 2020Article
- In vivo expression technology and 5' end mapping of the Borrelia burgdorferi transcriptome identify novel RNAs expressed during mammalian infection.Nucleic acids research · 2017Article
- Molecular dissection of a Borrelia burgdorferi in vivo essential purine transport system.Infection and immunity · 2015Article
- BB0238, a presumed tetratricopeptide repeat-containing protein, is required during Borrelia burgdorferi mammalian infection.Infection and immunity · 2014Article
- In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice.PLoS pathogens · 2013Article
- Convergent evolution of modularity in metabolic networks through different community structures.BMC evolutionary biology · 2012Article
- Borrelia burgdorferi harbors a transport system essential for purine salvage and mammalian infection.Infection and immunity · 2012Article
- Article
- Helicobacter pylori relies primarily on the purine salvage pathway for purine nucleotide biosynthesis.Journal of bacteriology · 2012Article
- Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA.Microbiology (Reading, England) · 2011Article
- Lactobacillus reuteri 2'-deoxyribosyltransferase, a novel biocatalyst for tailoring of nucleosides.Applied and environmental microbiology · 2010Article
- GuaA and GuaB are essential for Borrelia burgdorferi survival in the tick-mouse infection cycle.Journal of bacteriology · 2009Article
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4 authors.
Funding
Abstract
Borrelia burgdorferi is an obligate parasite with a limited genome that severely narrows its metabolic and biosynthetic capabilities. Thus survival of this spirochaete in an arthropod vector and mammalian host requires that it can scavenge amino acids, fatty acids and nucleosides from a blood meal or various host tissues. Additionally, the utilization of ribonucleotides for DNA synthesis is further complicated by the lack of a ribonucleotide reductase for the conversion of nucleoside-5'-diphosphates to deoxynucleosides-5'-diphosphates. The data presented here demonstrate that B. burgdorferi must rely on host-derived sources of purine bases, deoxypurines and deoxypyrimidines for the synthesis of DNA. However, if deoxyguanosine (dGuo) is limited in host tissue, the enzymatic activities of a 2'-deoxyribosyltransferase (DRTase, encoded by bb0426), IMP dehydrogenase (GuaB) and GMP synthase (GuaA) catalyse the multistep conversion of hypoxanthine (Hyp) to dGMP for DNA synthesis. This pathway provides additional biochemical flexibility for B. burgdorferi when it colonizes and infects different host tissues.
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