ReviewCancer science2009
Cytokine gene-mediated immunotherapy: current status and future perspectives.
Review in Cancer science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 62 citations in OpenAlex.
- Plasma cytokines as potential response indicators to dietary freeze-dried black raspberries in colorectal cancer patients.Nutrition and cancer · 2012Trial
- The application of nanoparticles-based ferroptosis, pyroptosis and autophagy in cancer immunotherapy.Journal of nanobiotechnology · 2024Review
- Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy.Journal for immunotherapy of cancer · 2019Review
- Article
- Intestinal mononuclear cells primed by systemic interleukin-12 display long-term ability to aggravate colitis in mice.Immunology · 2017Article
- Recent Successes and Future Directions in Immunotherapy of Cutaneous Melanoma.Frontiers in immunology · 2017Review
- Dendritic cell-based immunotherapy.Cell research · 2017Review
- Safety and antitumor effect of oncolytic and helper-dependent adenoviruses expressing interleukin-12 variants in a hamster pancreatic cancer model.Gene therapy · 2015Article
- IL-12 is required for mTOR regulation of memory CTLs during viral infection.Genes and immunity · 2014Article
- The colony-stimulating factors and cancer.Cancer immunology research · 2013Review
- Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model.Molecular cancer · 2013Article
- Preparation and characterization of monoclonal antibodies against VSTM1.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2013Article
- Recent developments in oncolytic adenovirus-based immunotherapeutic agents for use against metastatic cancers.Cancer gene therapy · 2013Review
- Pharmacokinetics of combined gene therapy expressing constitutive human GM-CSF and hyperthermia-regulated human IL-12.Journal of experimental & clinical cancer research : CR · 2013Article
- Ustekinumab in psoriasis immunopathology with emphasis on the Th17-IL23 axis: a primer.Journal of biomedicine & biotechnology · 2012Review
- Oncolytic adenovirus co-expressing IL-12 and IL-18 improves tumor-specific immunity via differentiation of T cells expressing IL-12Rβ2 or IL-18Rα.Gene therapy · 2011Article
- The immuno-regulatory effects of Schisandra chinensis and its constituents on human monocytic leukemia cells.Molecules (Basel, Switzerland) · 2011Article
- Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation.Transplantation · 2011Article
- Bioelectric applications for treatment of melanoma.Cancers · 2010Article
- HSV Recombinant Vectors for Gene Therapy.The open virology journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent understanding of the molecular events crucial in overcoming immunosuppressive tumor microenvironments and generating effective antitumor immunity provides us with the wreath opportunity to manipulate genes that have a key role in antitumor immune responses. Granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-12 (IL-12) are two indispensable cytokines for activating dendritic cells and boosting the strong immune responses against cancer. In this review, we describe the antitumor mechanisms and clinical application of gene-modified tumor cells and dendritic cells to secrete GM-CSF or IL-12, respectively, in various preclinical and clinical settings. The principles operative in these vaccination strategies may prove applicable to other immunotherapy strategies, especially in combination with other therapeutic modalities, such as chemotherapy and targeted therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.