ArticleLipids2009
Effect of bilayer phospholipid composition and curvature on ligand transfer by the alpha-tocopherol transfer protein.
Article in Lipids, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Vitamin E and Phosphoinositides Regulate the Intracellular Localization of the Hepatic α-Tocopherol Transfer Protein.The Journal of biological chemistry · 2016Article
- Complexity of vitamin E metabolism.World journal of biological chemistry · 2016Review
- Article
- Mechanisms of recognition and binding of α-TTP to the plasma membrane by multi-scale molecular dynamics simulations.Frontiers in molecular biosciences · 2015Article
- Mechanisms for the prevention of vitamin E excess.Journal of lipid research · 2013Review
- Altered vitamin E status in Niemann-Pick type C disease.Journal of lipid research · 2011Article
- The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP).Journal of molecular biology · 2011Article
- Mammalian diseases of phosphatidylinositol transfer proteins and their homologs.Clinical lipidology · 2010Article
- Synthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E.The Journal of organic chemistry · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We report here our preliminary investigations on the mechanism of alpha-TTP-mediated ligand transfer as assessed using fluorescence resonance energy transfer (FRET) assays. These assays monitor the movement of the model alpha-tocopherol fluorescent derivative ((R)-2,5,7,8-tetramethyl-chroman-2-[9-(7-nitro-benzo[1,2,5]oxadiazol-4-yl amino)-nonyl]-chroman-6-ol; NBD-Toc) from protein to acceptor vesicles containing the fluorescence quencher TRITC-PE. We have found that alpha-TTP utilizes a collisional mechanism of ligand transfer requiring direct protein-membrane contact, that rates of ligand transfer are greater to more highly curved lipid vesicles, and that such rates are insensitive to the presence of anionic phospholipids in the acceptor membrane. These results point to hydrophobic features of alpha-TTP dominating the binding energy between protein and membrane.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.