ArticleJournal of neuropathology and experimental neurology2009
Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain.
Article in Journal of neuropathology and experimental neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Homeobox Genes in Cancers: From Carcinogenesis to Recent Therapeutic Intervention.Frontiers in oncology · 2021Review
- Integrin β3/Akt signaling contributes to platelet-induced hemangioendothelioma growth.Scientific reports · 2017Article
- The role of epigenetics in the endothelial cell shear stress response and atherosclerosis.The international journal of biochemistry & cell biology · 2015Review
- Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
- A comparison of genome-wide DNA methylation patterns between different vascular tissues from patients with coronary heart disease.PloS one · 2015Article
- Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis.The Journal of clinical investigation · 2014Article
- Adipose tissue angiogenesis: impact on obesity and type-2 diabetes.Biochimica et biophysica acta · 2014Review
- Article
- The dual roles of homeobox genes in vascularization and wound healing.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Hemangiomas are angiogenesis-dependent benign vascular tumors that can rupture and cause intracranial hemorrhages. We previously showed that the transcription factor homeobox A5 (HoxA5), which is absent in activated angiogenic endothelial cells can block angiogenesis. Here, we investigated whether restoring expression of HoxA5 blocks hemangioma growth by transplanting mouse hemangioendothelioma endothelial cells (EOMA) or HoxA5-expressing EOMA cells into the brains of mice. The EOMA cells induced brain hemangiomas characterized by large cystlike spaces lined by thin walls of endothelial cells surrounded by scant smooth muscle cells. When HoxA5-expressing EOMA cells were injected, lesion volumes were reduced between 5- and 20-fold compared with the EOMA control group (p < 0.05). Restoration of HoxA5 was associated with increased thrombospondin-2, which inhibits angiogenesis and reduced hypoxia-inducible factor 1alpha expression. These data suggest that restoring HoxA5 can attenuate experimental brain hemangioma development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.