ArticleRNA biology
Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
Article in RNA biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Meta-analyses of the relationship between five CXCL8 gene polymorphisms and overall cancer risk, and a case-control study of oral cancer.BMC oral health · 2024Pooled it
- The role of microRNA-608 polymorphism on the susceptibility and survival of cancer: a meta-analysis.Aging · 2018Pooled it
- A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk.PloS one · 2014Pooled it
- Article
- Polymorphisms in miRNA Genes Targeting the AMPK Signaling Pathway are Associated with Cervical Cancer Susceptibility in a Han Chinese Population.International journal of general medicine · 2024Article
- The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review.Journal of personalized medicine · 2022Review
- Schizophrenia Risk Mediated by microRNA Target Genes Overlapped by Genome-Wide Rare Copy Number Variation in 22q11.2 Deletion Syndrome.Frontiers in genetics · 2022Article
- MicroRNAs in Genetic Etiology of Human Diseases.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The associations and roles of microRNA single-nucleotide polymorphisms in cervical cancer.International journal of medical sciences · 2021Review
- Nei Endonuclease VIII-like 2 Gene rs8191670 Polymorphism affects the Sensitivity of Non-small Cell Lung Cancer to Cisplatin by binding with MiR-548a.Journal of Cancer · 2020Article
- Network Profiling of Brain-Expressed X-Chromosomal MicroRNA Genes Implicates Shared Key MicroRNAs in Intellectual Disability.Journal of molecular neuroscience : MN · 2019Article
- A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women.Breast cancer research : BCR · 2018Article
- The Role of Exportin-5 in MicroRNA Biogenesis and Cancer.Genomics, proteomics & bioinformatics · 2018Review
- MiRNAs and miRNA Polymorphisms Modify Drug Response.International journal of environmental research and public health · 2016Review
- Genetic association analysis of miRNA SNPs implicates MIR145 in breast cancer susceptibility.BMC medical genetics · 2015Article
- Association Analysis of MET Gene Polymorphism with Papillary Thyroid Carcinoma in a Chinese Population.International journal of endocrinology · 2015Article
- Article
- Identification of miR-423 and miR-499 polymorphisms on affecting the risk of hepatocellular carcinoma in a large-scale population.Genetic testing and molecular biomarkers · 2014Article
- Association between a variant in microRNA-646 and the susceptibility to hepatocellular carcinoma in a large-scale population.TheScientificWorldJournal · 2014Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Human microRNAs (miRNAs) are potent regulators of gene expression and thus involved in a broad range of biological processes. The objective of this study was to update the properties of human miRNAs and to search for SNPs and CNVs with potential effects on them. Based on the miRBase 13.0 database, we identified 380 (53.9%) precursor miRNAs (pre-miRNAs) embedded in gene loci that are enriched in biological processes such as "neuronal activities", "cell cycle" and "protein phosphorylation" (Bonferroni p < 0.05). Gene lengths of the pre-miRNA host genes are significantly larger than other genes in the genome (p < 2.2E-16). Using data mining public resources, we performed a genome-scale search for the regulatory polymorphisms in the loci of pre-miRNAs and their related genes. Altogether, we found 187 SNPs in the pre-miRNAs, 497 consensus SNPs in the seed-matching untranslated regions of target genes, 385 CNVs harboring pre-miRNA precursors and 9 CNVs covering important miRNA processing genes. We also noticed that minimum free energy changed by pre-miRNA-residing SNPs could be ranked by the order from low to high as the SNPs in the loop domain, the SNPs in the adjacent stem and basal stem domains, and the SNPs in mature miRNA and its complementary sequence domains (p = 0.0065). With a full list of miRNA-related polymorphisms, this study will facilitate future association studies between the genetic polymorphisms in miRNA targets or pre-miRNAs and the disease susceptibility or therapeutic outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.