ArticleNucleic acids research1991
Members of the zinc finger protein gene family sharing a conserved N-terminal module.
Article in Nucleic acids research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
- Expression of ZNF695 Transcript Variants in Childhood B-Cell Acute Lymphoblastic Leukemia.Genes · 2019Article
- C2H2-Type Zinc Finger Proteins: Evolutionarily Old and New Partners of the Nuclear Hormone Receptors.Nuclear receptor signaling · 2018Review
- Sequencing, analysis, and annotation of expressed sequence tags for Camelus dromedarius.PloS one · 2010Article
- Evolution of C2H2-zinc finger genes and subfamilies in mammals: species-specific duplication and loss of clusters, genes and effector domains.BMC evolutionary biology · 2008Article
- Cloning and characterization of a novel KRAB-domain-containing zinc finger gene (ZNF284L).Molecular biology reports · 2006Article
- Conserved interaction between distinct Krüppel-associated box domains and the transcriptional intermediary factor 1 beta.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins.Journal of molecular evolution · 1995Article
- Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Proteins of the Xenopus laevis zinc finger multigene family as targets for CK II phosphorylation.Molecular and cellular biochemistry · 1995Article
- A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein.Molecular and cellular biology · 1994Article
- Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins.Nucleic acids research · 1994Article
- The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Gene structure and alternative splicing of XFG 5-1, a X. laevis Zn finger protein with RNA homopolymer binding activity.Molecular biology reports · 1993Article
- RNA binding properties and evolutionary conservation of the Xenopus multifinger protein Xfin.Nucleic acids research · 1993Article
- Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.The EMBO journal · 1993Article
- A novel X-linked member of the human zinc finger protein gene family: isolation, mapping, and expression.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Expression cloning of a novel zinc finger protein that binds to the c-fos serum response element.Molecular and cellular biology · 1992Article
- New nucleotide sequence data on the EMBL File Server.Nucleic acids research · 1992Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the isolation of human members of a sub-family of structurally related finger protein genes. These potentially encode polypeptides containing finger motifs of the Krüppel type at the C-terminus, and a conserved amino acid module at the N-terminus; because of its invariant location the latter is referred to as finger preceding box (FPB). The FPB, detected also in previously described finger proteins from human, mouse and Xenopus, extends over approximately 65 amino acids and appears to be composed of two contiguous modules: FPB-A (residues 1-42) and FPB-B (residues 43-65). The latter is absent in some of the members analyzed. Elements A and B and the zinc finger domain are encoded by separate exons in the ZNF2 gene, a human member of this sub-family. The positioning of introns within this gene is remarkable. One intron flanks and a second interrupts the first codon of the FPB-A and FPB-B modules, respectively. A third intron occurs a few nucleotides downstream of FPB-B marking its separation from the remainder of the coding sequences. This organization, together with the absence of FPB-B in some cDNAs, supports the hypothesis that mRNAs encoding polypeptides that include one, both or none of the FPB-A and FPB-B modules may be assembled through alternative splicing pathways. Northern analyses showed that members of this sub-family are expressed as multiple transcripts in several cell lines. The sequences of distinct cDNAs homologous to the ZNF2 gene indicate that alternative splicing events adjoin either coding or non coding exons to the FPB sequences.
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