ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2009
Individual variation in macronutrient regulation measured by proton magnetic resonance spectroscopy of human plasma.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The Diurnal Blood Metabolome and Effects of Vitamin D Supplementation: A Randomised Crossover Trial in Postmenopausal Women.International journal of molecular sciences · 2022Trial
- Macronutrient, Energy, and Bile Acid Metabolism Pathways Altered Following a Physiological Meal Challenge, Relative to Fasting, among Guatemalan Adults.The Journal of nutrition · 2020Trial
- Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome-A Review.Metabolites · 2021Review
- Application of high-resolution metabolomics to identify biological pathways perturbed by traffic-related air pollution.Environmental research · 2021Article
- Metabolomics and microbial composition increase insight into the impact of dietary differences in cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- A biplot correlation range for group-wise metabolite selection in mass spectrometry.BioData mining · 2019Article
- Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.Journal of mass spectrometry : JMS · 2016Article
- (1)H NMR- based metabolomics approaches as non- invasive tools for diagnosis of endometriosis.International journal of reproductive biomedicine · 2016Article
- Metabolomics and Its Application to Acute Lung Diseases.Frontiers in immunology · 2016Review
- Article
- Comparative transcriptomics and metabolomics in a rhesus macaque drug administration study.Frontiers in cell and developmental biology · 2014Article
- Signal intensities derived from different NMR probes and parameters contribute to variations in quantification of metabolites.PloS one · 2014Article
- Multifractal analysis for nutritional assessment.PloS one · 2013Article
- Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.PloS one · 2013Article
- Advances in Nutritional Metabolomics.Current Metabolomics · 2013Article
- Nutritional metabolomics: progress in addressing complexity in diet and health.Annual review of nutrition · 2012Review
- Daily Variation of Serum Acylcarnitines and Amino Acids.Metabolomics : Official journal of the Metabolomic Society · 2012Article
- Clustering Based on Periodicity in High-Throughput Time Course Data.Statistical analysis and data mining · 2011Article
- Metabolic effects of albumin therapy in acute lung injury measured by proton nuclear magnetic resonance spectroscopy of plasma: a pilot study.Critical care medicine · 2011Article
- The emerging field of quantitative blood metabolomics for biomarker discovery in critical illnesses.American journal of respiratory and critical care medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Proton nuclear magnetic resonance ((1)H-NMR) spectroscopy of plasma provides a global metabolic profiling method that shows promise for clinical diagnostics. However, cross-sectional studies are complicated by a lack of understanding of intraindividual variation, and this limits experimental design and interpretation of data. The present study determined the diurnal variation detected by (1)H NMR spectroscopy of human plasma. Data reduction methods revealed three time-of-day metabolic patterns, which were associated with morning, afternoon, and night. Major discriminatory regions for these time-of-day patterns included the various kinds of lipid signals (-CH(2)- and -CH(2)OCOR), and the region between 3 and 4 ppm heavily overlapped with amino acids that had alpha-CH and alpha-CH(2). The phasing and duration of time-of-day patterns were variable among individuals, apparently because of individual difference in food processing/digestion and absorption and clearance of macronutrient energy sources (fat, protein, carbohydrate). The times of day that were most consistent among individuals, and therefore most useful for cross-sectional studies, were fasting morning (0830-0930), postprandial afternoon (1430-1630), and nighttime samples (0430-0530). Importantly, the integrated picture of metabolism provided by (1)H-NMR spectroscopy of plasma suggests that this approach is suitable to study complex regulatory processes, including eating patterns/eating disorders, upper gastrointestinal functions (gastric emptying, pancreatic, biliary functions), and absorption/clearance of macronutrients. Hence, (1)H-NMR spectroscopy of plasma could provide a global metabolic tolerance test to assess complex processes involved in disease, including eating disorders and the range of physiological processes causing dysregulation of energy homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.