ArticleProceedings of the National Academy of Sciences of the United States of America2009
Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Humanization of theGenes · 2026Article
- Deletion of Elongator Protein 1 (Elp1) relieves heterochromatin defects in a Pol II mutant of Schizosaccharomyces pombe.Genetics · 2026Article
- Polymeric nature of tandemly repeated genes enhances assembly of constitutive heterochromatin in fission yeast.Communications biology · 2023Article
- Three human RNA polymerases interact with TFIIH via a common RPB6 subunit.Nucleic acids research · 2022Article
- Conserved strategies of RNA polymerase I hibernation and activation.Nature communications · 2021Article
- The gammaherpesviral TATA-box-binding protein directly interacts with the CTD of host RNA Pol II to direct late gene transcription.PLoS pathogens · 2020Article
- Yeast Spt6 Reads Multiple Phosphorylation Patterns of RNA Polymerase II C-Terminal Domain In Vitro.Journal of molecular biology · 2020Article
- Repeat-Specific Functions for the C-Terminal Domain of RNA Polymerase II in Budding Yeast.G3 (Bethesda, Md.) · 2018Article
- Structure and dynamics of the RNAPII CTDsome with Rtt103.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Multisubunit DNA-Dependent RNA Polymerases from Vaccinia Virus and Other Nucleocytoplasmic Large-DNA Viruses: Impressions from the Age of Structure.Microbiology and molecular biology reviews : MMBR · 2017Review
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- Distributive O-GlcNAcylation on the Highly Repetitive C-Terminal Domain of RNA Polymerase II.Biochemistry · 2016Article
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- Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.Molecular cell · 2015Article
- Identification and refinement of two strong constitutive promoters for gene expression system of Schizosaccharomyces pombe.World journal of microbiology & biotechnology · 2014Article
- Structural basis for promoter specificity switching of RNA polymerase by a phage factor.Genes & development · 2014Article
- Architecture of an RNA polymerase II transcription pre-initiation complex.Science (New York, N.Y.) · 2013Article
- The C-terminal domain of Rpb1 functions on other RNA polymerase II subunits.Molecular cell · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The second structure of a eukaryotic RNA polymerase II so far determined, that of the enzyme from the fission yeast Schizosaccharomyces pombe, is reported here. Comparison with the previous structure of the enzyme from the budding yeast Saccharomyces cerevisiae reveals differences in regions implicated in start site selection and transcription factor interaction. These aspects of the transcription mechanism differ between S. pombe and S. cerevisiae, but are conserved between S. pombe and humans. Amino acid changes apparently responsible for the structural differences are also conserved between S. pombe and humans, suggesting that the S. pombe structure may be a good surrogate for that of the human enzyme.
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