ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Correlation between DNA Methylation and Cell Proliferation Identifies New Candidate Predictive Markers in Meningioma.Cancers · 2022Article
- Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Frontiers in cell and developmental biology · 2021Review
- Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling.Molecular psychiatry · 2017Article
- How Does p73 Cause Neuronal Defects?Molecular neurobiology · 2016Review
- Article
- Delayed hippocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higher and longer-term expression of p63 in the ischemic hippocampus.Neural regeneration research · 2015Article
- Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system.Cell cycle (Georgetown, Tex.) · 2015Article
- P73 and P63: The siblings that work together in neurodevelopment.Cell cycle (Georgetown, Tex.) · 2015Article
- Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.Endocrine-related cancer · 2014Article
- Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life.PloS one · 2014Article
- The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- p63 Regulates adult neural precursor and newly born neuron survival to control hippocampal-dependent Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Apoptotic cell death in neuroblastoma.Cells · 2013Article
- Tumor suppressive pathways in the control of neurogenesis.Cellular and molecular life sciences : CMLS · 2013Review
- p53 Family: Role of Protein Isoforms in Human Cancer.Journal of nucleic acids · 2012Article
- Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins.The Journal of biological chemistry · 2011Article
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Authors and funding
5 authors.
Funding
Abstract
The molecular mechanisms that regulate survival of embryonic neural precursors are still relatively ill-defined. Here, we have asked whether the p53 family member p63 plays any role during this developmental window, focusing on the embryonic cerebral cortex. We show that genetic knockdown of p63 either in culture or in the embryonic telencephalon causes apoptosis of cortical precursors and newly born cortical neurons, and that this can be rescued by expression of DeltaNp63, but not TAp63 isoforms. This cortical precursor apoptosis is the consequence of deregulated p53 activity, since both basal precursor apoptosis and that induced by loss of p63 are rescued by coincident genetic silencing of p53. Finally, we demonstrate that the third p53 family member, DeltaNp73, does not regulate survival of cortical precursor cells, but that it collaborates with DeltaNp63 to ensure the survival of newly born cortical neurons. Thus, the balance of DeltaNp63 versus p53 determines the life versus death of embryonic cortical precursors, a role that these p53 family members may well play in other populations of developing and/or adult neural precursors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.