ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Renshaw cell recurrent inhibition improves physiological tremor by reducing corticomuscular coupling at 10 Hz.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed.
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- The neuromechanical of Beta-band corticomuscular coupling within the human motor system.Frontiers in neuroscience · 2024Review
- Combined effect of contraction type and intensity on corticomuscular coherence during isokinetic plantar flexions.European journal of applied physiology · 2023Article
- Soccer heading immediately alters brain function and brain-muscle communication.Frontiers in human neuroscience · 2023Article
- The Existence of the StartReact Effect Implies Reticulospinal, Not Corticospinal, Inputs Dominate Drive to Motoneurons during Voluntary Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
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- Genetic targeting of adult Renshaw cells using a Calbindin 1 destabilized Cre allele for intersection with Parvalbumin or Engrailed1.Scientific reports · 2021Article
- Spinal astroglial cannabinoid receptors control pathological tremor.Nature neuroscience · 2021Article
- Specific modulation of corticomuscular coherence during submaximal voluntary isometric, shortening and lengthening contractions.Scientific reports · 2021Article
- Force variability is mostly not motor noise: Theoretical implications for motor control.PLoS computational biology · 2021Article
- Spatial and Temporal Arrangement of Recurrent Inhibition in the Primate Upper Limb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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2 authors.
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Abstract
Corticomuscular coherence between the primary motor cortex (M1) and hand muscle electromyograms (EMG) occurs at approximately 20 Hz but is rarely seen at approximately 10 Hz. This is unexpected, because M1 has oscillations at both frequencies, which are effectively transmitted to the spinal cord via the corticospinal tract. We have previously speculated that a specific "neural filter" may selectively reduce coherence at approximately 10 Hz. This would have functional utility in minimizing physiological tremor, which often has a dominant component around this frequency. Recurrent inhibition via Renshaw cells in the spinal cord is a putative neural substrate for such a filter. Here we investigate this system in more detail with a biophysically based computational model. Renshaw cell recurrent inhibition reduced EMG oscillations at approximately 10 Hz, and also reduced corticomuscular coherence at this frequency (from 0.038 to 0.014). Renshaw cell inhibitory feedback also generated synchronous oscillations in the motoneuron pool at approximately 30 Hz. We show that the effects at 10 Hz and 30 Hz can both be understood from the dynamics of the inhibitory feedback loop. We conclude that recurrent inhibition certainly plays an important role in reducing 10 Hz oscillations in muscle, thereby decreasing tremor amplitude. However, our quantitative results suggest it is unlikely to be the only system for tremor reduction, and probably acts in concert with other neural circuits which remain to be elucidated.
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