ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
The role of neurotrophins in the seasonal-like growth of the avian song control system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 51 citations in OpenAlex.
- Seabirds in crisis: Plastic ingestion induces proteomic signatures of multiorgan failure and neurodegeneration.Science advances · 2025Article
- Adult neurogenesis is necessary for functional regeneration of a forebrain neural circuit.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Perineuronal nets in HVC and plasticity in male canary song.PloS one · 2021Article
- Testosterone stimulates perineuronal nets development around parvalbumin cells in the adult canary brain in parallel with song crystallization.Hormones and behavior · 2020Article
- Seasonal changes of perineuronal nets and song learning in adult canaries (Serinus canaria).Behavioural brain research · 2020Article
- Brain-Derived Neurotrophic Factor Has a Transsynaptic Trophic Effect on Neural Activity in an Adult Forebrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Rapamycin blocks the neuroprotective effects of sex steroids in the adult birdsong system.Developmental neurobiology · 2019Article
- Sex Steroids, Adult Neurogenesis, and Inflammation in CNS Homeostasis, Degeneration, and Repair.Frontiers in endocrinology · 2018Review
- Adult Neurogenesis Leads to the Functional Reconstruction of a Telencephalic Neural Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Inhibition of TrkB limits development of the zebra finch song system.Brain research · 2016Article
- Sex and age differences in brain-derived neurotrophic factor and vimentin in the zebra finch song system: Relationships to newly generated cells.The Journal of comparative neurology · 2016Article
- Genetic regulation of sex differences in songbirds and lizards.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Network analysis of microRNA and mRNA seasonal dynamics in a highly plastic sensorimotor neural circuit.BMC genomics · 2015Article
- Neurogenesis in the adult avian song-control system.Cold Spring Harbor perspectives in biology · 2015Review
- Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity.Frontiers in neuroendocrinology · 2015Review
- Regulatory mechanisms of testosterone-stimulated song in the sensorimotor nucleus HVC of female songbirds.BMC neuroscience · 2014Article
- Tracheosyringeal nerve transection in juvenile male zebra finches decreases BDNF in HVC and RA and the projection between them.Neuroscience letters · 2014Article
- Reactive neurogenesis in response to naturally occurring apoptosis in an adult brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Postsynaptic neural activity regulates neuronal addition in the adult avian song control system.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Testosterone modulation of angiogenesis and neurogenesis in the adult songbird brain.Neuroscience · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The avian song control system undergoes pronounced seasonal plasticity in response to photoperiod and hormonal cues. The action of testosterone (T) and its metabolites in the song nucleus HVC is both necessary and sufficient to promote breeding season-like growth of its efferent nuclei RA (robust nucleus of the arcopallium) and Area X, suggesting that HVC may release a trophic factor such as brain-derived neurotrophic factor (BDNF) into RA and X. BDNF is involved in many forms of adult neural plasticity in other systems and is present in the avian song system. We used a combination of in situ hybridization and intracerebral infusions to test whether BDNF plays a role in the seasonal-like growth of the song system in adult male white-crowned sparrows. BDNF mRNA levels increased in HVC in response to breeding conditions, and BDNF infusion into RA was sufficient to promote breeding-like changes in somatic area and neuronal density. Expression of the mRNA for the Trk B receptor of BDNF, however, did not vary with seasonal conditions in either HVC or RA. Local blockade of BDNF activity in RA via infusion of Trk-Fc fusion proteins inhibited the response to breeding conditions. Our results indicate that BDNF is sufficient to promote the seasonal plasticity in somatic area and cell density in RA, although NT-3 may also contribute to this process, and suggest that HVC may be a presynaptic source of increased levels of BDNF in RA of breeding-condition birds.
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