ArticleMolecular biology of the cell2009
Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.
Article in Molecular biology of the cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 48 citations in OpenAlex.
- Molecular Characterization of Nine TRAF Genes in Yellow Catfish (International journal of molecular sciences · 2023Article
- TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling.Molecular cancer research : MCR · 2022Article
- Genome-wide analysis of genes encoding core components of the ubiquitin system during cerebral cortex development.Molecular brain · 2022Article
- The Research Progress in Physiological and Pathological Functions of TRAF4.Frontiers in oncology · 2022Review
- An Overview of the Posttranslational Modifications and Related Molecular Mechanisms in Diabetic Nephropathy.Frontiers in cell and developmental biology · 2021Review
- Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction.PLoS biology · 2018Article
- Pitx1 regulates cement gland development in Xenopus laevis through activation of transcriptional targets and inhibition of BMP signaling.Developmental biology · 2018Article
- Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4.Cell adhesion & migration · 2018Article
- Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.Oncotarget · 2017Article
- Regulation of Ubiquitin Enzymes in the TGF-β Pathway.International journal of molecular sciences · 2017Review
- Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition.Biochimica et biophysica acta · 2015Article
- The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling.Development (Cambridge, England) · 2014Article
- TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus.Molecular and cellular biochemistry · 2014Article
- Expression and anti-apoptotic function of TRAF4 in human breast cancer MCF-7 cells.Oncology letters · 2014Article
- TRAF4 is a novel phosphoinositide-binding protein modulating tight junctions and favoring cell migration.PLoS biology · 2013Article
- Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells.The Journal of biological chemistry · 2013Article
- A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.Cellular and molecular life sciences : CMLS · 2013Review
- Different activation of TRAF4 and TRAF6 in inflammatory bowel disease.Mediators of inflammation · 2013Article
- Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The transforming growth factor (TGF)-beta superfamily regulates cell proliferation, apoptosis, differentiation, migration, and development. Canonical TGFbeta signals are transduced to the nucleus via Smads in both major signaling branches, bone morphogenetic protein (BMP) or Activin/Nodal/TGFbeta. Smurf ubiquitin (Ub) ligases attenuate these pathways by targeting Smads and other signaling components for degradation by the 26S proteasome. Here, we identify tumor necrosis factor (TNF)-receptor-associated factor-4 (TRAF4) as a new target of Smurf1, which polyubiquitylates TRAF4 to trigger its proteasomal destruction. Unlike other TRAF family members, which mediate signal transduction by TNF, interleukin, or Toll-like receptors, we find that TRAF4 potentiates BMP and Nodal signaling. In the frog Xenopus laevis, TRAF4 mRNA is stored maternally in the egg animal pole, and in the embryo it is expressed in the gastrula marginal zone, neural plate, and cranial and trunk neural crest. Knockdown of embryonic TRAF4 impairs signaling, neural crest development and neural folding, whereas TRAF4 overexpression boosts signaling and expands the neural crest. In human embryonic kidney 293 cells, small interfering RNA knockdown of Smurf1 elevates TRAF4 levels, indicating endogenous regulation of TRAF4 by Smurf1. Our results uncover new functions for TRAF4 as a Smurf1-regulated mediator of BMP and Nodal signaling that are essential for neural crest development and neural plate morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.