ArticleProceedings of the National Academy of Sciences of the United States of America2009
Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Multiple cell populations generate macrophage progenitors in the early yolk sac.Cellular and molecular life sciences : CMLS · 2022Article
- The Fetal-to-Adult Hematopoietic Stem Cell Transition and its Role in Childhood Hematopoietic Malignancies.Stem cell reviews and reports · 2021Review
- Indispensable role of Galectin-3 in promoting quiescence of hematopoietic stem cells.Nature communications · 2021Article
- Monocyte/Macrophage Lineage Cells From Fetal Erythromyeloid Progenitors Orchestrate Bone Remodeling and Repair.Frontiers in cell and developmental biology · 2021Review
- Cellular Basis of Embryonic Hematopoiesis and Its Implications in Prenatal Erythropoiesis.International journal of molecular sciences · 2020Review
- Splitomicin, a SIRT1 Inhibitor, Enhances Hematopoietic Differentiation of Mouse Embryonic Stem Cells.International journal of stem cells · 2019Article
- Mouse Yolk Sac Hematopoiesis.Frontiers in cell and developmental biology · 2018Review
- F4/80Journal of immunology research · 2016Article
- Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- B-1a cell diversity: nontemplated addition in B-1a cell Ig is determined by progenitor population and developmental location.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Common developmental pathway for primitive erythrocytes and multipotent hematopoietic progenitors in early mouse development.Stem cell reports · 2013Article
- Generation of red blood cells from human embryonic/induced pluripotent stem cells for blood transfusion.International journal of hematology · 2012Review
- Immature B cells preferentially switch to IgE with increased direct Sμ to Sε recombination.The Journal of experimental medicine · 2011Article
- Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Temporal specification of blood progenitors from mouse embryonic stem cells and induced pluripotent stem cells.Development (Cambridge, England) · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
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Abstract
The hematopoietic system of mice is established during the early to midgestational stage of development. However, the earliest lymphohematopoietic progenitors that appear during mouse development have been less well characterized compared with the hematopoietic stem cell compartment of fetal liver and bone marrow. We isolated the earliest lymphohematopoietic progenitors by using embryonic stem (ES) cell culture in vitro. Cells with the c-Kit(+)Lin(-) cell surface phenotype were present abundantly in ES cells cocultured with stromal cell lines. We further separated the cells into two distinct cell subsets based on AA4.1 expression. Although AA4.1(+) and AA4.1(-) cells had equivalent potency to generate myeloid cell lineages, the lymphoid potential in ES-cell-derived cells was largely restricted to the cells expressing AA4.1. The same cell type was present abundantly in the early yolk sac and in fewer numbers (approximately 5% of that in the yolk sac) in the caudal half of the developing embryos. These data suggest that AA4.1 is a cell surface marker that can identify the earliest lymphohematopoietic progenitors in mouse development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.