ArticleThe Journal of nutrition2009
Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice.
Article in The Journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Characterization of fatty acid composition of bone marrow by 3-T MRI in patients with Crohn's disease.European radiology · 2026Article
- Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity.Membranes · 2021Review
- Diet and Gut Microbes Act Coordinately to Enhance Programmed Cell Death and Reduce Colorectal Cancer Risk.Digestive diseases and sciences · 2020Review
- Effect of feeding male mice with palm, fish, and sunflower oils on sperm characteristics and sex ratio of offspring.Veterinary research forum : an international quarterly journal · 2020Article
- Omega-3 fatty acids, membrane remodeling and cancer prevention.Molecular aspects of medicine · 2018Review
- Effects of different dietary n-6/n-3 polyunsaturated fatty acid ratios on boar reproduction.Lipids in health and disease · 2016Article
- Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt.Biochimica et biophysica acta · 2016Article
- Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial.American journal of epidemiology · 2013Article
- Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model.Journal of lipid research · 2012Article
- Interactive effects of fatty acid and butyrate-induced mitochondrial Ca²⁺ loading and apoptosis in colonocytes.Cancer · 2011Article
- Dietary fish oil reduces DNA adduct formation while estradiol upregulates apoptosis in response to DNA damage in the rat colon.Digestive diseases and sciences · 2011Article
- Dietary fish oil promotes colonic apoptosis and mitochondrial proton leak in oxidatively stressed mice.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- A chemoprotective fish oil- and pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis.The Journal of nutrition · 2011Article
- Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes.International journal of cancer · 2011Article
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Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
We recently demonstrated that (n-3) PUFA trigger the induction of apoptosis in the colon by enhancing phospholipid oxidation and mitochondrial Ca2+ accumulation. To further elucidate the mechanisms regulating oxidative stress-induced apoptosis in vivo, a 2 x 2 experiment was designed using both wild type (control) and manganese-dependent superoxide dismutase (SOD2) heterozygous knockout mice (SOD2(+/-)), which exhibit increased mitochondrial oxidative stress. Mice were fed diets differing only in the type of fat [corn oil or fish oil containing (n-3) PUFA] at 15% by weight for 4 wk. Dietary (n-3) PUFA treatment enhanced (22%) apoptosis in colonic crypts. In addition, SOD2 haploinsufficiency enhanced (20%) apoptosis, which was further increased (36%) by (n-3) PUFA feeding. Dietary lipid source and genotype interactively modulated nitrotyrosine levels (P = 0.027) and inflammation (P = 0.032). These findings demonstrate that the proapoptotic effects of (n-3) PUFA are enhanced in oxidatively stressed SOD2(+/-) mice. Thus, (n-3) PUFA appear to promote an oxidation-reduction imbalance in the intestine, which may directly or indirectly trigger apoptosis and thereby reduce colon cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.