ArticleJournal of experimental botany2009
Inefficient double-strand DNA break repair is associated with increased fasciation in Arabidopsis BRCA2 mutants.
Article in Journal of experimental botany, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Essential role of theBiotechnologia · 2023Article
- An insight into understanding the coupling between homologous recombination mediated DNA repair and chromatin remodeling mechanisms in plant genome: an update.Cell cycle (Georgetown, Tex.) · 2021Review
- Phyllotaxis: from classical knowledge to molecular genetics.Journal of plant research · 2021Review
- Article
- Rice OsBRCA2 Is Required for DNA Double-Strand Break Repair in Meiotic Cells.Frontiers in plant science · 2020Article
- Protecting DNA from errors and damage: an overview of DNA repair mechanisms in plants compared to mammals.Cellular and molecular life sciences : CMLS · 2017Review
- A DNA2 Homolog Is Required for DNA Damage Repair, Cell Cycle Regulation, and Meristem Maintenance in Plants.Plant physiology · 2016Article
- Genome-Wide Analysis Indicates Lineage-Specific Gene Loss during Papilionoideae Evolution.Genome biology and evolution · 2016Article
- Physiological changes and anti-oxidative responses of Arabidopsis plants after acute and chronic γ-irradiation.Radiation and environmental biophysics · 2014Article
- Maintenance of genome stability in plants: repairing DNA double strand breaks and chromatin structure stability.Frontiers in plant science · 2014Review
- Differentially expressed genes in response to gamma-irradiation during the vegetative stage in Arabidopsis thaliana.Molecular biology reports · 2014Article
- Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.Clinical cancer research : an official journal of the American Association for Cancer Research · 2012Review
- Identification of plant RAD52 homologs and characterization of the Arabidopsis thaliana RAD52-like genes.The Plant cell · 2011Article
- BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thaliana.Nucleic acids research · 2011Article
- Homologs of breast cancer genes in plants.Frontiers in plant science · 2011Article
- Characterization of Brca2-deficient plants excludes the role of NHEJ and SSA in the meiotic chromosomal defect phenotype.PloS one · 2011Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BRCA2 is a breast tumour susceptibility factor with functions in maintaining genome stability through ensuring efficient double-strand DNA break (DSB) repair via homologous recombination. Although best known in vertebrates, fungi, and higher plants also possess BRCA2-like genes. To investigate the role of Arabidopsis BRCA2 genes in DNA repair in somatic cells, transposon insertion mutants of the AtBRCA2a and AtBRCA2b genes were identified and characterized. atbrca2a-1 and atbrca2b-1 mutant plants showed hypersensitivity to genotoxic stresses compared to wild-type plants. An atbrca2a-1/atbrca2b-1 double mutant showed an additive increase in sensitivity to genotoxic stresses compared to each single mutant. In addition, it was found that atbrca2 mutant plants displayed fasciation and abnormal phyllotaxy phenotypes with low incidence, and that the ratio of plants exhibiting these phenotypes is increased by gamma-irradiation. Interestingly, these phenotypes were also induced by gamma-irradiation in wild-type plants. Moreover, it was found that shoot apical meristems of the atbrca2a-1/atbrca2b-1 double mutant show altered cell cycle progression. These data suggest that inefficient DSB repair in the atbrca2a-1/atbrca2b-1 mutant leads to disorganization of the programmed cell cycle of apical meristems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.