ArticleThe Journal of biological chemistry2009
Cortactin is a functional target of E-cadherin-activated Src family kinases in MCF7 epithelial monolayers.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Repeat DNA methylation is modulated by adherens junction signaling.Communications biology · 2024Article
- Article
- Remodeling of E-cadherin subcellular localization during cell dissemination.Molecular biology of the cell · 2023Article
- Par-3 family proteins in cell polarity & adhesion.The FEBS journal · 2022Review
- Cortactin function in invadopodia.Small GTPases · 2020Review
- Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis.NPJ breast cancer · 2019Article
- Visualizing Spatiotemporal Dynamics of Intercellular Mechanotransmission upon Wounding.ACS photonics · 2018Article
- Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.Nature communications · 2017Article
- Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells.PLoS computational biology · 2017Article
- Formin-mediated actin polymerization at cell-cell junctions stabilizes E-cadherin and maintains monolayer integrity during wound repair.Molecular biology of the cell · 2016Article
- Article
- An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions.Molecular biology of the cell · 2015Article
- Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens.The Journal of biological chemistry · 2014Article
- Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma.Cell research · 2014Article
- A bigger picture: classical cadherins and the dynamic actin cytoskeleton.Nature reviews. Molecular cell biology · 2012Review
- Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells.The Journal of biological chemistry · 2012Article
- Cortactin in cell migration and cancer at a glance.Journal of cell science · 2012Review
- Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation.PloS one · 2012Article
- Regulation of adherens junction dynamics by phosphorylation switches.Journal of signal transduction · 2012Article
- Integrins and cadherins join forces to form adhesive networks.Journal of cell science · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Src family kinases (SFKs) signal in response to E-cadherin to support cadherin adhesion and the integrity of cell-cell contacts (McLachlan, R. W., Kraemer, A., Helwani, F. M., Kovacs, E. M., and Yap, A. S. (2007) Mol. Biol. Cell 18, 3214-3223). We now identify the actin-regulatory protein, cortactin, as a target of E-cadherin-activated SFK signaling. Tyr-phosphorylated cortactin was found at cell-cell contacts in established epithelial monolayers, and cortactin became acutely tyrosine-phosphorylated when E-cadherin adhesion was engaged. In all circumstances, cortactin tyrosine phosphorylation was blocked by inhibiting SFK signaling. Importantly, Tyr-phosphorylated cortactin was necessary to preserve the integrity of cadherin contacts and the perijunctional actin cytoskeleton. Moreover, expression of a phosphomimetic cortactin mutant could prevent SFK blockade from disrupting cadherin organization, thereby placing cortactin functionally downstream of SFK signaling at cadherin adhesions. We conclude that SFK and cortactin constitute an important signaling pathway that functionally links E-cadherin adhesion and the actin cytoskeleton.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.