ArticlePflugers Archiv : European journal of physiology1991
Length-dependent myosin phosphorylation and contraction of arterial smooth muscle.
Article in Pflugers Archiv : European journal of physiology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cross-bridge apparent rate constants of human gallbladder smooth muscle.Journal of muscle research and cell motility · 2011Article
- Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries.American journal of physiology. Heart and circulatory physiology · 2008Article
- Bronchospasm and its biophysical basis in airway smooth muscle.Respiratory research · 2004Review
- Perturbed equilibria of myosin binding in airway smooth muscle: bond-length distributions, mechanics, and ATP metabolism.Biophysical journal · 2000Article
- The length dependency of calcium activated contractions in the femoral artery smooth muscle studied with different methods of skinning.Journal of muscle research and cell motility · 2000Article
- Ca2+ -induced Ca2+ desensitization of myosin light chain phosphorylation and contraction in phasic smooth muscle.Molecular and cellular biochemistry · 1999Article
- The effect of length on the sensitivity to phenylephrine and calcium in intact and skinned vascular smooth muscle.Journal of muscle research and cell motility · 1999Article
- Energetic cost of activation processes during contraction of swine arterial smooth muscle.The Journal of physiology · 1997Article
- Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries.The Journal of physiology · 1997Article
- Dependence of force on length at constant cross-bridge phosphorylation in the swine carotid media.The Journal of physiology · 1995Article
- Resting load regulates cytosolic calcium-force relationship of the contraction of bovine cerebrovascular smooth muscle.The Journal of physiology · 1995Article
- Calcium and smooth muscle contraction.Molecular and cellular biochemistry · 1994Review
- Models of the mechanism for crossbridge attachment in smooth muscle.Journal of muscle research and cell motility · 1993Article
- Adenosine 5'-triphosphate consumption by smooth muscle as predicted by the coupled four-state crossbridge model.Biophysical journal · 1992Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Ca2+, calmodulin-dependent myosin light chain phosphorylation is generally considered to be an important regulatory mechanism of smooth muscle contraction. We investigated the length dependence of myosin phosphorylation and active stress induced by K+ depolarization in arterial smooth muscle by measuring the two variables in the swine carotid media held at three steady-state tissue lengths-optimal length for contraction (Lo), 1.5 Lo, and slack length. We found that the length dependence of peak and steady-state myosin phosphorylation with respect to tissue length was different. Peak myosin phosphorylation was highest at Lo but lower at both slack length and 1.5 Lo, whereas steady-state myosin phosphorylation was similar at both Lo and 1.5 Lo, but lower at slack length. Stretching tissues to 1.5 Lo did not significantly change the steady-state myosin phosphorylation induced by K+ depolarization, but releasing tissues to slack length was associated with a 42% decrease in the steady-state myosin phosphorylation induced by K+ depolarization. These data indicated that one or more steps coupling membrane depolarization and Ca(2+)-dependent myosin phosphorylation were length sensitive. Additional data from skinned tissue experiments indicated that the length-sensitive step was not the coupling between Ca2+ and myosin phosphorylation. Therefore, these data together suggest that one or more steps coupling membrane depolarization and the increase in cytosolic Ca2+ concentration are length sensitive.
Indexed as
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Registered trials
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