Evidence map›Paper›PMID 19457416›Full record

ReviewGastroenterology2009

Diagnosis and treatment of acute or persistent diarrhea.

Sean W Pawlowski, Cirle Alcantara Warren, Richard Guerrant

2 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph

Review in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03166670 completednot on this mapstarted 2018, after this paper: background citation

Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.

TypeobservationalSponsorAssiut UniversityRan2018 to 2021Enrolled100ConditionsDiarrhea, SecretoryArmsstool examination, real time polymerase chain reaction
NCT04491799 completednot on this mapstarted 2019, after this paper: background citation

Fecal Calprotectin Level in Differentiating Between Inflammatory and Non-inflammatory Diarrhea in Patients With Nosocomial Diarrhea

TypeobservationalSponsorMahidol UniversityRan2019 to 2020Enrolled135ConditionsDiarrhea, CalprotectinArmsFecal calprotectin
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 231 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Adjunctive use ofTranslational gastroenterology and hepatology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Predictive value of fecal calprotectin and lactoferrin levels for negative outcomes in Clostridioides difficile infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sean W PawlowskiDivision of Infectious Disease and International Health, Center for Global Health, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
Cirle Alcantara Warren
Richard Guerrant
Center for Global Health · US

Funding

INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
NIAID NIH HHS T32 AI007046
6 · The paper itself

Abstract

Studies of microbial pathogens and the toxins they produce are important for determining the mechanisms by which they cause disease and spread throughout a population. Some bacteria produce secretory enterotoxins (such as cholera toxin or the heat-labile or stable enterotoxins produced by Escherichia coli) that invade cells directly. Others invade cells or produce cytotoxins (such as those produced by Shigella, enteroinvasive E coli, or Clostridium difficile) that damage cells or trigger host responses that cause small or large bowel diseases (such as enteroaggregative or enteropathogenic E coli or Salmonella). Viruses (such as noroviruses and rotaviruses) and protozoa (such as Cryptosporidium, Giardia, or Entamoeba histolytica) disrupt cell functions and cause short- or long-term disease. Much epidemiologic data about these pathogens have been collected from community- and hospital-acquired settings, as well as from patients with traveler's or persistent diarrhea. These studies have led to practical approaches for prevention, diagnosis, and treatment.

Indexed as

BacteriaDiarrheaAcute DiseaseAnti-Bacterial AgentsAntibodies, BacterialDiagnosis, DifferentialDNA, BacterialEnzyme-Linked Immunosorbent AssayHumansPolymerase Chain ReactionAnti-Bacterial AgentsAntibodies, BacterialDNA, Bacterial

Identifiers

PMID19457416
PMCPMC2723735
OpenAlexW1974285350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.