Evidence map›Paper›PMID 19457415›Full record

ReviewGastroenterology2009

Helicobacter pylori in health and disease.

Timothy L Cover, Martin J Blaser

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05374980 (The Effects of Fermented Milk Product With Probiotic on Helicobacter Pylori Infection, Gut Microbiome and Metabolism.), which is not on this map. Cited by 352 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 3 pooled it
45.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05374980 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effects of Fermented Milk Product With Probiotic on Helicobacter Pylori Infection, Gut Microbiome and Metabolism.

TypeinterventionalSponsorTaichung Veterans General HospitalRan2022 to 2023Enrolled51ConditionsProbiotic, Gut Microbiota, Helicobacter Pylori Infection, Insulin ResistanceArmsYogurt, Placebo
3 · Its place in the literature

Who cites it

352 citing papers in PubMed, 3 syntheses or guidelines pooled it, 698 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  8. Article
  9. Multiple TonB-dependent transport systems inInfection and immunity · 2026
    Article
  10. Article
  11. Methylation Dynamics inMicroorganisms · 2026
    Article
  12. Community-BasedPublic health reports (Washington, D.C. : 1974) · 2026
    Article
  13. Review
  14. Review
  15. Crystal structure of carbon-nitrogen hydrolase from Helicobacter pylori G27.Acta crystallographica. Section F, Structural biology communications · 2026
    Article
  16. Article
  17. Determination of Potential Inhibitors againstCurrent pharmaceutical design · 2026
    Review
  18. Article
  19. On the Role of Food in the Transmission ofFoods (Basel, Switzerland) · 2025
    Review
  20. The multi-kingdom cancer microbiome.Nature microbiology · 2025
    Review

292 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Timothy L CoverDepartment of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee 37232, USA. timothy.L.cover@vanderbilt.edu
Martin J Blaser
New York University · USVanderbilt University · US

Funding

Structure-function analysis of H. pylori VacAR01AI039657 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TIMOTHY L COVER · 1996 to 2026
$8.3M
MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATIONR01GM063270 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BLASER, MARTIN J · 2000 to 2013
$3.1M
Analysis of the H. Pylori cag pathogenicity islandR01AI068009 · NIAID · VANDERBILT UNIVERSITY · PI COVER, TIMOTHY L · 2008 to 2012
$1.9M
NIAID NIH HHS R01 AI039657NIAID NIH HHS R01 AI068009NIAID NIH HHS R01 AI39657NIGMS NIH HHS R01 GM063270NIGMS NIH HHS R01GM63270
6 · The paper itself

Abstract

Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H pylori is usually the numerically dominant gastric microorganism. H pylori typically does not cause any adverse effects, but it is associated with an increased risk of noncardia gastric adenocarcinoma, gastric lymphoma, and peptic ulcer. Disorders such as esophageal diseases and childhood-onset asthma were recently reported to occur more frequently in individuals who lack H pylori than in H pylori-positive persons. In this review, we discuss biologic factors that allow H pylori to colonize the human stomach, mechanisms by which H pylori increases the risk of peptic ulcer disease and noncardia gastric adenocarcinoma, and potential benefits that H pylori might confer to humans.

Indexed as

Helicobacter InfectionsHelicobacter pyloriHumansMorbidityRisk FactorsStomach DiseasesUnited States

Identifiers

PMID19457415
PMCPMC3644425
OpenAlexW2157442946

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.