ArticleMolecular ecology2009
Microsatellite analysis of genetic diversity among clinical and nonclinical Saccharomyces cerevisiae isolates suggests heterozygote advantage in clinical environments.
Article in Molecular ecology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High quality de novo genome assembly of the non-conventional yeast Kazachstania bulderi describes a potential low pH production host for biorefineries.Communications biology · 2023Article
- Whole genome sequencing of Canadian Saccharomyces cerevisiae strains isolated from spontaneous wine fermentations reveals a new Pacific West Coast Wine clade.G3 (Bethesda, Md.) · 2023Article
- Population genomics of the pathogenic yeast Candida tropicalis identifies hybrid isolates in environmental samples.PLoS pathogens · 2021Article
- Baker's Yeast Clinical Isolates Provide a Model for How Pathogenic Yeasts Adapt to Stress.Trends in genetics : TIG · 2019Review
- Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes inGenetics · 2019Article
- Mating in wild yeast: delayed interest in sex after spore germination.Molecular biology of the cell · 2018Article
- A Case Study of Genomic Instability in an Industrial Strain ofG3 (Bethesda, Md.) · 2018Article
- Genome-Wide Screen forG3 (Bethesda, Md.) · 2018Article
- The Influence of Polyploidy on the Evolution of Yeast Grown in a Sub-Optimal Carbon Source.Molecular biology and evolution · 2017Article
- Known mutator alleles do not markedly increase mutation rate in clinicalProceedings. Biological sciences · 2017Article
- Experimental Evolution Reveals Interplay between Sch9 and Polyploid Stability in Yeast.PLoS genetics · 2016Article
- Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation.G3 (Bethesda, Md.) · 2016Article
- The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen.Genome research · 2015Article
- The Genetics of Non-conventional Wine Yeasts: Current Knowledge and Future Challenges.Frontiers in microbiology · 2015Review
- Revisiting Mortimer's Genome Renewal Hypothesis: heterozygosity, homothallism, and the potential for adaptation in yeast.Advances in experimental medicine and biology · 2014Review
- Computational models for prediction of yeast strain potential for winemaking from phenotypic profiles.PloS one · 2013Article
- Biogeographical characterization of Saccharomyces cerevisiae wine yeast by molecular methods.Frontiers in microbiology · 2013Article
- Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity.Genome research · 2012Article
- Natural genetic variation in yeast longevity.Genome research · 2012Article
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2 authors.
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Abstract
The genetic structure of a global sample of 170 clinical and nonclinical Saccharomyces cerevisiae isolates was analysed using 12 microsatellite markers. High levels of genetic diversity were revealed both among the clinical and among the nonclinical S. cerevisiae isolates without significant differentiation between these two groups of isolates, rendering a single origin of pathogenic isolates unlikely. This suggests that S. cerevisiae is a true opportunistic pathogen, with a diversity of unrelated genetic backgrounds able to cause infections in humans, and that the ability of S. cerevisiae isolates to cause infections is likely due to a combination of their phenotypic plasticity and the immune system status of the exposed individuals. As was previously reported for bread, beer and wine strains and for environmental S. cerevisiae isolates, the microsatellite genotypes indicated ploidy level variation, from possibly haploid up to tetraploid, among clinical S. cerevisiae isolates. However, rather than haploid, sporulation proficiency and spore viability data indicated that most S. cerevisiae isolates that were mono-allelic at all examined microsatellite loci were likely homothallic and self-diploidized. Interestingly, the proportion of heterozygous clinical isolates was found to be significantly higher than the proportion of heterozygous nonclinical isolates, suggesting a selective advantage of heterozygous S. cerevisiae yeasts in clinical environments.
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