ArticleJournal of neurochemistry2009
p75NTR-dependent modulation of cellular handling of reactive oxygen species.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Taming the "death receptor": translating the first-in-class p75Journal of translational medicine · 2026Review
- p75NTR Modulation by LM11A-31 Counteracts Oxidative Stress and Cholesterol Dysmetabolism in a Rotenone-Induced Cell Model of Parkinson's Disease.Neurochemical research · 2025Article
- p75NTR Modulation Reduces Oxidative Stress and the Expression of Pro-Inflammatory Mediators in a Cell Model of Rett Syndrome.Biomedicines · 2024Article
- Drug-Tolerant Persister Cells in Cancer Therapy Resistance.Cancer research · 2022Review
- Cancer stem cells enrichment with surface markers CD271 and CD44 in human head and neck squamous cell carcinomas.Carcinogenesis · 2020Article
- Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress.Cell death & disease · 2020Article
- Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer.Theranostics · 2020Review
- Astaxanthin Ameliorates Ischemic-Hypoxic-Induced Neurotrophin Receptor p75 Upregulation in the Endothelial Cells of Neonatal Mouse Brains.International journal of molecular sciences · 2019Article
- CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma.Oncotarget · 2014Article
- Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior.Translational psychiatry · 2014Article
- p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma.Cancer chemotherapy and pharmacology · 2014Article
- Kidins220/ARMS is expressed in neuroblastoma tumors and stabilizes neurotrophic signaling in a human neuroblastoma cell line.Pediatric research · 2013Article
- Aiming at neuroblastoma and hitting other worthy targets.Journal of child neurology · 2013Review
- p75NTR: an enhancer of fenretinide toxicity in neuroblastoma.Cancer chemotherapy and pharmacology · 2013Article
- Structural characterization of the self-association of the death domain of p75(NTR.).PloS one · 2013Article
- Pharmacologic management of high-risk neuroblastoma in children.Paediatric drugs · 2011Review
- Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.Pediatric research · 2011Article
- Chopper is prodeath regardless of the effect of p75ICD on sensitivity to oxidative stress.Oxidative medicine and cellular longevity · 2011Article
- The child is father to the man: developmental roles for proteins of importance for neurodegenerative disease.Annals of neurology · 2010Review
- Necdin and TrkA contribute to modulation by p75NTR of resistance to oxidant stress.Experimental cell research · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Our previous studies demonstrated that p75NTR confers protection against oxidative stress-induced apoptosis upon PC12 cells; however, the mechanisms responsible for this effect are not known. The present studies reveal decreased mitochondrion membrane potential and increased generation of reactive oxygen species (ROS) in p75NTR-deficient PC12 cells as well as diminution of ROS generation after transfection of a full-length p75NTR construct into these cells. They also show that p75NTR deficiency attenuates activation of the phosphatidylinositol 3-kinase --> phospho-Akt/protein kinase B pathway in PC12 cells by oxidative stress or neurotrophic ligands and inhibition of Akt phosphorylation decreases the glutathione (GSH) content in PC12 cells. In addition, decreased de novo GSH synthesis and increased GSH consumption are observed in p75NTR-deficient cells. These findings indicate that p75NTR regulates cellular handling of ROS to effect a survival response to oxidative stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.