ArticleJournal of neurochemistry2009
Melanocortin potentiates leptin-induced STAT3 signaling via MAPK pathway.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Differential effects of leptin on adiponectin expression with weight gain versus obesity.International journal of obesity (2005) · 2016Trial
- Autophagy in hypothalamic POMC and AgRP neurons: mechanisms and therapeutic implications for obesity.International journal of obesity (2005) · 2026Review
- Endocrine effects of MEK and BRAF inhibitor therapy in paediatric patients: a tertiary centre experience.Journal of neuro-oncology · 2025Article
- The Importance of Melanocortin Receptors and Their Agonists in Pulmonary Disease.Frontiers in medicine · 2019Review
- Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network.Scientific reports · 2016Article
- α-Melanocyte-stimulating hormone ameliorates ocular surface dysfunctions and lesions in a scopolamine-induced dry eye model via PKA-CREB and MEK-Erk pathways.Scientific reports · 2015Article
- α-Melanocyte-stimulating hormone prevents glutamate excitotoxicity in developing chicken retina via MC4R-mediated down-regulation of microRNA-194.Scientific reports · 2015Article
- Intravitreal injection of ranibizumab and CTGF shRNA improves retinal gene expression and microvessel ultrastructure in a rodent model of diabetes.International journal of molecular sciences · 2014Article
- Article
- Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area.The Journal of comparative neurology · 2012Article
- Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis.Journal of molecular neuroscience : MN · 2012Article
- Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- C-reactive protein increases BBB permeability: implications for obesity and neuroinflammation.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2012Article
- Cytokine signaling modulates blood-brain barrier function.Current pharmaceutical design · 2011Review
- Central insulin and leptin-mediated autonomic control of glucose homeostasis.Trends in endocrinology and metabolism: TEM · 2011Review
- NFĸB is an unexpected major mediator of interleukin-15 signaling in cerebral endothelia.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2011Article
- Concepts for biologically active peptides.Current pharmaceutical design · 2010Review
- Article
- The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.Endocrine reviews · 2010Article
- Expression and signaling of novel IL15Ralpha splicing variants in cerebral endothelial cells of the blood-brain barrier.Journal of neurochemistry · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The co-existence of receptors for leptin and melanocortin in cerebral microvessels suggests possible interactions between leptin and alpha-melanocyte stimulating hormone (MSH) signaling. In this study, we showed that ObRb and melanocortin receptor MC3R and MC4R were present in enriched cerebral microvessels. To test the interactions between ObRb and MC3R or MC4R-mediated cellular signaling, we over-expressed these plasmids in RBE4 cerebral microvascular endothelial cells and HEK293 cells in culture. Activation of signal transducers and activators of transcription-3 (STAT3) in response to leptin was determined by western blotting and luciferase reporter assays. Production of cAMP downstream to melanocortin receptors was determined with a chemiluminescent ELISA kit. alphaMSH, which increased intracellular cAMP, also potentiated leptin-induced STAT3 activation. This potentiation was abolished by a specific MEK inhibitor, indicating the involvement of the mitogen-activated kinase pathway. Reversely, the effect of leptin on alphaMSH-induced cAMP production was minimal. Thus, melanocortin specifically potentiated STAT3 signaling downstream to ObRb by cross-talk with mitogen-activated kinase. The cooperation of ObRb and G protein-coupled receptors in cellular signaling may have considerable biological implications not restricted to feeding and obesity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.