ArticleJournal of neurochemistry2009
Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmission.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
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- Dexamethasone-Enhanced Continuous Online Microdialysis for Neuromonitoring of OACS chemical neuroscience · 2023Article
- Anesthesia and analgesia for experimental craniotomy in mice and rats: a systematic scoping review comparing the years 2009 and 2019.Frontiers in neuroscience · 2023Article
- Neural correlates of extrinsic and intrinsic outcome processing during learning in individuals with TBI: a pilot investigation.Brain imaging and behavior · 2022Article
- Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology.Behavioural pharmacology · 2018Review
- Cognitive fatigue in individuals with traumatic brain injury is associated with caudate activation.Scientific reports · 2017Article
- Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0.Journal of visualized experiments : JoVE · 2017Article
- COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment.Neurorehabilitation and neural repair · 2016Article
- Catecholamines and cognition after traumatic brain injury.Brain : a journal of neurology · 2016Review
- Fast-scan cyclic voltammetry demonstrates that L-DOPA produces dose-dependent, regionally selective bimodal effects on striatal dopamine kinetics in vivo.Journal of neurochemistry · 2016Article
- Developing a clinically relevant model of cognitive training after experimental traumatic brain injury.Neurorehabilitation and neural repair · 2015Article
- Methamphetamine-induced neurotoxicity disrupts pharmacologically evoked dopamine transients in the dorsomedial and dorsolateral striatum.Neurotoxicity research · 2014Article
- Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup.Journal of neurotrauma · 2014Review
- Biomarkers of cognitive dysfunction in traumatic brain injury.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats.Journal of neurotrauma · 2013Article
- Traumatic brain injury reduces striatal tyrosine hydroxylase activity and potassium-evoked dopamine release in rats.Brain research · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Traumatic brain injury features deficits are often ameliorated by dopamine (DA) agonists. We have previously shown deficits in striatal DA neurotransmission using fast scan cyclic voltammetry after controlled cortical impact (CCI) injury that are reversed after daily treatment with the DA uptake inhibitor methylphenidate (MPH). The goal of this study was to determine how a single dose of MPH (5 mg/kg) induces changes in basal DA and metabolite levels and with electrically evoked overflow (EO) DA in the striatum of CCI rats. MPH-induced changes in EO DA after a 2-week daily pre-treatment regime with MPH was also assessed. There were no baseline differences in basal DA or metabolite levels. MPH injection significantly increased basal [DA] output in dialysates for control but not injured rats. Also, MPH injection increased striatal peak EO [DA] to a lesser degree in CCI (176% of baseline) versus control rats (233% of baseline). However, daily pre-treatment with MPH resulted in CCI rats having a comparable increase in EO [DA] after MPH injection when compared with controls. The findings further support the concept that daily MPH therapy restores striatal DA neurotransmission after CCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.