ArticleJournal of the American Chemical Society2009
Macrocyclic design strategies for small, stable parallel beta-sheet scaffolds.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Synthetic Preparation of the Macrocyclolipopeptide Dysoxylactam A for Potent P-glycoprotein Inhibition.The Journal of organic chemistry · 2025Article
- Transition Dipole Strength as a Quantitative Tool for Protein Secondary Structure Analysis.The journal of physical chemistry. B · 2025Article
- Macrocyclic β-Sheets Stabilized by Hydrogen Bond Surrogates.Angewandte Chemie (International ed. in English) · 2023Article
- Bispidine as a β-strand nucleator: from a β-arch to self-assembled cages and vesicles.Chemical science · 2021Article
- Covalent Linkage and Macrocylization Preserve and Enhance Synergistic Interactions in Catalytic Amyloids.Chembiochem : a European journal of chemical biology · 2021Article
- Structure-Property Relationship Study ofThe Journal of organic chemistry · 2020Article
- Improved Stability and Tunable Functionalization of Parallel β-Sheets via Multicomponent N-Alkylation of the Turn Moiety.Angewandte Chemie (International ed. in English) · 2020Article
- Evolving a Peptide: Library Platforms and Diversification Strategies.International journal of molecular sciences · 2019Review
- Systematic Targeting of Protein-Protein Interactions.Trends in pharmacological sciences · 2016Review
- Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Angewandte Chemie (International ed. in English) · 2015Review
- Anatomy of β-strands at protein-protein interfaces.ACS chemical biology · 2014Article
- Parallel β-sheet vibrational couplings revealed by 2D IR spectroscopy of an isotopically labeled macrocycle: quantitative benchmark for the interpretation of amyloid and protein infrared spectra.Journal of the American Chemical Society · 2012Article
- Parallel β-sheet secondary structure is stabilized and terminated by interstrand disulfide cross-linking.Journal of the American Chemical Society · 2012Article
- Impact of strand length on the stability of parallel-β-sheet secondary structure.Angewandte Chemie (International ed. in English) · 2011Article
- Giant macrolactams based on β-sheet peptides.The Journal of organic chemistry · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Pairs of short peptide strands can be induced to adopt an antiparallel beta-sheet secondary structure in aqueous solution via a macrocyclic constraint, as illustrated by many natural and designed peptides. We show that an analogous strategy is successful for creation of small units of parallel beta-sheet secondary structure in aqueous solution. Cyclization in this case requires nonpeptide segments for N-to-N and C-to-C interstrand linkage. Surprisingly, we find that only one of these segments needs to be preorganized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.