ArticleJournal of gastroenterology2009
Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population.
Article in Journal of gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Association between cyclooxygenase-2 (COX-2) 8473 T > C polymorphism and cancer risk: a meta-analysis and trial sequential analysis.BMC cancer · 2018Pooled it
- Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.Mutation researchPooled it
- Early detection of gallbladder cancer: Current status and future perspectives.World journal of clinical oncology · 2025Review
- Article
- Current and New Biomarkers for Early Detection, Prognostic Stratification, and Management of Gallbladder Cancer Patients.Cancers · 2020Review
- Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.World journal of gastroenterology · 2017Review
- The inflammatory inception of gallbladder cancer.Biochimica et biophysica acta · 2016Review
- Caspase-8 polymorphisms and risk of oral squamous cell carcinoma.Experimental and therapeutic medicine · 2015Article
- Cyclooxygenase-2 -1195G>A (rs689466) polymorphism and cancer susceptibility: an updated meta-analysis involving 50,672 subjects.International journal of clinical and experimental medicine · 2015Article
- Cyclooxygenase-2 polymorphisms and bladder cancer risk: a meta-analysis based on case-control studies.International journal of clinical and experimental medicine · 2015Article
- Association of potentially functional genetic variants of PLCE1 with gallbladder cancer susceptibility in north Indian population.Journal of gastrointestinal cancer · 2013Article
- SNPs in PTGS2 and LTA predict pain and quality of life in long term lung cancer survivors.Lung cancer (Amsterdam, Netherlands) · 2012Article
- Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes.PloS one · 2011Article
- Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma.Molecular and cellular biochemistry · 2011Article
- DNMT3B -579 G>T promoter polymorphism and risk of gallbladder carcinoma in North Indian population.Journal of gastrointestinal cancer · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclooxygenase-2 (PTGS2) overexpression has been implicated in various cancers. We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer. MATERIALS AND
methodsThe study included 167 gallbladder cancer cases and 184 controls. Genotyping was done by polymerase chain reaction-restriction fragment length polymorphism. Risk was estimated using unconditional logistic regression.
resultsSignificant risk was observed in the presence of PTGS2 -1195GA (P=0.006; odds ratio=2.00; 95% confidence interval=1.2-3.3) and AA genotypes (P=0.050; odds ratio=2.98; 95% confidence interval=1.0-8.9). Combined risk due to GA+AA genotypes was 2.12 (P=0.002; 95% confidence interval=1.3-3.3; P-trend=0.001). Sub-grouping showed a risk due to the PTGS2 -1195(GA+AA) genotype in males (P=0.007; odds ratio=2.97; 95% confidence interval=1.3-6.5), patients without gallstones (P=0.001; odds ratio=2.53; 95% confidence interval=1.4-4.7) and with late-onset gallbladder cancer (P=0.012; odds ratio=1.99; 95% confidence interval=1.1-3.4). Gallbladder cancer patients who used tobacco were at increased risk in the presence of the PTGS2 -765GC genotype (P=0.018; odds ratio=2.96; 95% confidence interval=1.2-7.2). DISCUSSION: An association of PTGS2 -1195G>A polymorphism with gallbladder cancer, particularly in patients without gallstones, suggests a direct role of PTGS2 in cancer development.
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