ArticleEvolutionary bioinformatics online2007
Spectral analysis of sequence variability in basic-helix-loop-helix (bHLH) protein domains.
Article in Evolutionary bioinformatics online, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Accurate discrimination of bHLH domains in plants, animals, and fungi using biologically meaningful sites.BMC evolutionary biology · 2012Article
- Phylogenetic analysis and classification of the fungal bHLH domain.Molecular biology and evolution · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The basic helix-loop-helix (bHLH) family of transcription factors is used as a paradigm to explore structural implications of periodicity patterns in amino acid sequence variability. A Boltzmann-Shannon entropy profile represents site-by-site amino acid variation in the bHLH domain. Spectral analysis of almost 200 bHLH sequences documents the periodic nature of the bHLH sequence variation. Spectral analyses provide strong evidence that the patterns of amino acid variation in large numbers of sequences conform to the classical alpha-helix three-dimensional structure periodicity of 3.6 amino acids per turn. Multivariate indices of amino acid physiochemical attributes derived from almost 500 amino acid attributes are used to provide information regarding the underlying causal components of the bHLH sequence variability. Five multivariate attribute indices are used that reflect patterns in i) polarity - hydrophobicity - accessibility, ii) propensity for secondary structures, iii) molecular volume, iv) codon composition and v) electrostatic charge. Multiple regression analyses of the entropy values as dependent variables and the factor score means and variances as independent variables are used to partition variation in entropy values into their underlying causal structural components.
Indexed as
Identifiers
19455213PMC2674655What OpenQuestion holds
Registered trials
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