ReviewNature reviews. Neuroscience2009
Stress signalling pathways that impair prefrontal cortex structure and function.
Review in Nature reviews. Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02940808 (The Effects of a Single Administration of a Moderate Dose of Caffeine on Cognitive Control and Spontaneous EEG Theta/Beta Ratio), which is not on this map. Cited by 1,346 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of a Single Administration of a Moderate Dose of Caffeine on Cognitive Control and Spontaneous EEG Theta/Beta Ratio
Who cites it
1,346 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Stress and alcohol impact network states involved in emotional processing: relevance of comorbid AUD and psychiatric illnesses.Psychopharmacology · 2026Pooled it
- Biomarker evidence for the pathophysiological mechanisms of insomnia: a systematic review and meta-analysis.Frontiers in immunology · 2026Pooled it
- Assessing neurocognitive outcomes in PTSD: a multilevel meta-analytical approach.European journal of psychotraumatology · 2025Pooled it
- An Overview of Stress Analysis Based on Physiological Signals: Systematic Review of Open Datasets and Current Trends.Sensors (Basel, Switzerland) · 2025Pooled it
- A Meta-Analysis of the Effects of Early Life Stress on the Prefrontal Cortex Transcriptome Reveals Long-Term Downregulation of Myelin-Related Gene Expression.Brain and behavior · 2025Pooled it
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- Hypnosis reshapes multilevel stress response and enhances executive performance in stressed medical students.Scientific reports · 2026Trial
- Efficacy of Repetitive Transcranial Magnetic Stimulation on Postoperative Delirium in Elderly Patients Undergoing Non-Cardiac Major Surgery: A Randomized Controlled Trial.Brain and behavior · 2026Trial
- Self-Soothing Touch Reduces Momentary Stress, Fatigue, and Loneliness Comparable to Brief Meditation: A Randomised Controlled Trial.Stress and health : journal of the International Society for the Investigation of Stress · 2026Trial
- Emotional intelligence training improves stress regulation and performance in high-stress occupations.Scientific reports · 2026Trial
- Trial
- Acute Stress Impacts Executive-Social Function: Evidence From Prefrontal Activation and fNIRS-Based Hyperscanning.Brain and behavior · 2026Trial
- The Effect of Music on Resistance to Mental Fatigue: Evidence from the EEG Power Spectrum.Applied psychophysiology and biofeedback · 2025Trial
- Virtual reality enhanced mindfulness and yoga intervention for postpartum depression and anxiety in the post COVID era.Scientific reports · 2025Trial
- Alterations in gray matter microstructure and functional connectivity after acute stress.European journal of psychotraumatology · 2026Article
- Surrogate resilience and clinical titration of presence in the open intensive care unit: a systematic narrative synthesis.International journal of nursing studies advances · 2026Review
- Psychological Adaptation During Prolonged War-Related Stress in Ukraine: A Narrative Review.Health science reports · 2026Article
- Associations between polygenic risk for obesity, body mass index and cognitive performance: Age as moderating factor.Brain, behavior, & immunity - health · 2026Article
- Article
1,286 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The prefrontal cortex (PFC) - the most evolved brain region - subserves our highest-order cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental effects of stress exposure. Even quite mild acute uncontrollable stress can cause a rapid and dramatic loss of prefrontal cognitive abilities, and more prolonged stress exposure causes architectural changes in prefrontal dendrites. Recent research has begun to reveal the intracellular signalling pathways that mediate the effects of stress on the PFC. This research has provided clues as to why genetic or environmental insults that disinhibit stress signalling pathways can lead to symptoms of profound prefrontal cortical dysfunction in mental illness.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.