ReviewMolecular psychiatry2009
Neurobiological trait abnormalities in bipolar disorder.
Review in Molecular psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.Molecular psychiatry · 2021Pooled it
- Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder.bioRxiv : the preprint server for biology · 2026Article
- Cerebral Energy Status and Altered Metabolism in Early Severe TBI: First Results of a ProspectiveNeurocritical care · 2021Article
- A 7 Tesla Amygdalar-Hippocampal Shape Analysis of Lithium Response in Bipolar Disorder.Frontiers in psychiatry · 2021Article
- Association Between Bipolar Disorder and Low Bone Mass: A Cross-Sectional Study With Newly Diagnosed, Drug-Naïve Patients.Frontiers in psychiatry · 2020Article
- A pilot fMRI study of lithium response in bipolar disorder.Psychiatry research. Neuroimaging · 2019Article
- Article
- Trait-related alterations of N-acetylaspartate in euthymic bipolar patients: A longitudinal proton magnetic resonance spectroscopy study.Journal of affective disorders · 2016Article
- Mood disorders in the elderly: prevalence, functional impact, and management challenges.Neuropsychiatric disease and treatment · 2016Review
- Decreased brain PME/PDE ratio in bipolar disorder: a preliminary (31) P magnetic resonance spectroscopy study.Bipolar disorders · 2015Article
- Brain abnormalities in bipolar disorder detected by quantitative T1ρ mapping.Molecular psychiatry · 2015Article
- Disturbed tryptophan metabolism in cardiovascular disease.Current medicinal chemistry · 2014Review
- Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.JAMA psychiatry · 2014Article
- Accurate and Fully Automatic Hippocampus Segmentation Using Subject-Specific 3D Optimal Local Maps Into a Hybrid Active Contour Model.IEEE journal of translational engineering in health and medicine · 2014Article
- Integrated neurobiology of bipolar disorder.Frontiers in psychiatry · 2014Review
- Cytokines in bipolar disorder: paving the way for neuroprogression.Neural plasticity · 2014Review
- Chemokines in bipolar disorder: trait or state?European archives of psychiatry and clinical neuroscience · 2013Article
- Brain gray matter phenotypes across the psychosis dimension.Psychiatry research · 2012Article
- Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology.Biology of mood & anxiety disorders · 2012Article
- Size and shape of the caudate nucleus in individuals with bipolar affective disorder.The Australian and New Zealand journal of psychiatry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dissecting trait neurobiological abnormalities in bipolar disorder (BD) from those characterizing episodes of mood disturbance will help elucidate the aetiopathogenesis of the illness. This selective review highlights the immunological, neuroendocrinological, molecular biological and neuroimaging abnormalities characteristic of BD, with a focus on those likely to reflect trait abnormalities by virtue of their presence in euthymic patients or in unaffected relatives of patients at high genetic liability for illness. Trait neurobiological abnormalities of BD include heightened pro-inflammatory function and hypothalamic-pituitary-adrenal axis dysfunction. Dysfunction in the intracellular signal transduction pathway is indicated by elevated protein kinase A activity and altered intracellular calcium signalling. Consistent neuroimaging abnormalities include the presence of ventricular enlargement and white matter abnormalities in patients with BD, which may represent intermediate phenotypes of illness. In addition, spectroscopy studies indicate reduced prefrontal cerebral N-acetylaspartate and phosphomonoester concentrations. Functional neuroimaging studies of euthymic patients implicate inherently impaired neural networks subserving emotional regulation, including anterior limbic, ventral and dorsal prefrontal regions. Despite heterogeneous samples and conflicting findings pervading the literature, there is accumulating evidence for the existence of neurobiological trait abnormalities in BD at various scales of investigation. The aetiopathogenesis of BD will be better elucidated by future clinical research studies, which investigate larger and more homogenous samples and employ a longitudinal design to dissect neurobiological abnormalities that are underlying traits of the illness from those related to episodes of mood exacerbation or pharmacological treatment.
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Registered trials
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