ArticleMolecular systems biology2009
Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters.
Article in Molecular systems biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Format-Preserving Reduction of Canonical Nonlinear Models.Bulletin of mathematical biology · 2026Article
- Glutamine alleviates the toxicity of externally applied amino acids in Arabidopsis.Frontiers in plant science · 2026Article
- Multiscale Mathematical Modeling in Systems Biology: A Framework to Boost Plant Synthetic Biology.Plants (Basel, Switzerland) · 2025Review
- Design patterns of biological cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- The Arabidopsis leaf quantitative atlas: a cellular and subcellular mapping through unified data integration.Quantitative plant biology · 2024Article
- A mutation in THREONINE SYNTHASE 1 uncouples proliferation and transition domains of the root apical meristem: experimental evidence and in silico proposed mechanism.Development (Cambridge, England) · 2022Article
- Carbon and nitrogen metabolic regulation in freshwater plantFrontiers in plant science · 2022Article
- Interkingdom Comparison of Threonine Metabolism for Stem Cell Maintenance in Plants and Animals.Frontiers in cell and developmental biology · 2021Review
- Metrics for regulated biochemical pathway systems.Bioinformatics (Oxford, England) · 2019Article
- Construction of a network describing asparagine metabolism in plants and its application to the identification of genes affecting asparagine metabolism in wheat under drought and nutritional stress.Food and energy security · 2018Article
- ChloroKB: A Web Application for the Integration of Knowledge Related to Chloroplast Metabolic Network.Plant physiology · 2017Article
- A Regulatory Hierarchy of the Arabidopsis Branched-Chain Amino Acid Metabolic Network.The Plant cell · 2017Article
- Identification of Metabolic Pathway Systems.Frontiers in genetics · 2016Article
- Tracing regulatory routes in metabolism using generalised supply-demand analysis.BMC systems biology · 2015Article
- Analysis of Loss-of-Function Mutants in Aspartate Kinase and Homoserine Dehydrogenase Genes Points to Complexity in the Regulation of Aspartate-Derived Amino Acid Contents.Plant physiology · 2015Article
- From Genetics to Functional Genomics: Improvement in Drought Signaling and Tolerance in Wheat.Frontiers in plant science · 2015Review
- Plant metabolic modeling: achieving new insight into metabolism and metabolic engineering.The Plant cell · 2014Review
- Crystal structure ofBiotechnology reports (Amsterdam, Netherlands) · 2014Article
- PENDISC: a simple method for constructing a mathematical model from time-series data of metabolite concentrations.Bulletin of mathematical biology · 2014Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aspartate-derived amino-acid pathway from plants is well suited for analysing the function of the allosteric network of interactions in branched pathways. For this purpose, a detailed kinetic model of the system in the plant model Arabidopsis was constructed on the basis of in vitro kinetic measurements. The data, assembled into a mathematical model, reproduce in vivo measurements and also provide non-intuitive predictions. A crucial result is the identification of allosteric interactions whose function is not to couple demand and supply but to maintain a high independence between fluxes in competing pathways. In addition, the model shows that enzyme isoforms are not functionally redundant, because they contribute unequally to the flux and its regulation. Another result is the identification of the threonine concentration as the most sensitive variable in the system, suggesting a regulatory role for threonine at a higher level of integration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.