ArticleJournal of immunology (Baltimore, Md. : 1950)2009
MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multiple Immune and Genetic Mechanisms Contribute to Cmv5s-Driven Susceptibility and Tissue Damage during Acute Murine Cytomegalovirus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Licensing Natural Killers for Antiviral Immunity.Pathogens (Basel, Switzerland) · 2021Review
- Control of Viral Infection by Natural Killer Cell Inhibitory Receptors.Cell reports · 2020Article
- Genome-Wide Exome Analysis ofG3 (Bethesda, Md.) · 2017Article
- Murine Cytomegalovirus Disrupts Splenic Dendritic Cell SubsetsFrontiers in immunology · 2017Article
- Acute Virus Control Mediated by Licensed NK Cells Sets Primary CD8+ T Cell Dependence on CD27 Costimulation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.PLoS pathogens · 2016Article
- The Attenuated Live Yellow Fever Virus 17D Infects the Thymus and Induces Thymic Transcriptional Modifications of Immunomodulatory Genes in C57BL/6 and BALB/C Mice.Autoimmune diseases · 2015Article
- MCMV avoidance of recognition and control by NK cells.Seminars in immunopathology · 2014Review
- Know Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control.Frontiers in immunology · 2014Review
- Multiparametric analysis of host response to murine cytomegalovirus in MHC class I-disparate mice reveals primacy of Dk-licensed Ly49G2+ NK cells in viral control.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Rapid discrimination of MHC class I and killer cell lectin-like receptor allele variants by high-resolution melt analysis.Immunogenetics · 2012Article
- Genetic approach to study lupus glomerulonephritis.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience.Current opinion in virology · 2011Review
- All is fair in virus-host interactions: NK cells and cytomegalovirus.Trends in molecular medicine · 2011Article
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- Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.The Journal of experimental medicine · 2011Article
- The impact of Ly49-NK cell-dependent recognition of MCMV infection on innate and adaptive immune responses.Journal of biomedicine & biotechnology · 2011Review
- Cytomegalovirus immunoevasin reveals the physiological role of "missing self" recognition in natural killer cell dependent virus control in vivo.The Journal of experimental medicine · 2010Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Essential NK cell-mediated murine CMV (MCMV) resistance is under histocompatibility-2(k) (H-2(k)) control in MA/My mice. We generated a panel of intra-H2(k) recombinant strains from congenic C57L.M-H2(k/b) (MCMV resistant) mice for precise genetic mapping of the critical interval. Recombination breakpoint sites were precisely mapped and MCMV resistance/susceptibility traits were determined for each of the new lines to identify the MHC locus. Strains C57L.M-H2(k)(R7) (MCMV resistant) and C57L.M-H2(k)(R2) (MCMV susceptible) are especially informative; we found that allelic variation in a 0.3-megabase interval in the class I D locus confers substantial difference in MCMV control phenotypes. When NK cell subsets responding to MCMV were examined, we found that Ly49G2(+) NK cells rapidly expand and selectively acquire an enhanced capacity for cytolytic functions only in C57L.M-H2(k)(R7). We further show that depletion of Ly49G2(+) NK cells before infection abrogated MCMV resistance in C57L.M-H2(k)(R7). We conclude that the MHC class I D locus prompts expansion and activation of Ly49G2(+) NK cells that are needed in H-2(k) MCMV resistance.
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