ArticlePhysiological genomics2009
Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart.
Article in Physiological genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
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- Mitochondrial transplantation: the advance to therapeutic application and molecular modulation.Frontiers in cardiovascular medicine · 2023Review
- Mitochondrial Transplantation for Ischemia Reperfusion Injury.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Mitochondrial transplantation by intra-arterial injection for acute kidney injury.American journal of physiology. Renal physiology · 2020Article
- Interrelationship Between Contractility, Protein Synthesis and Metabolism in Mantle of Juvenile Cuttlefish (Frontiers in physiology · 2019Article
- Mitochondrial transplantation: applications for pediatric patients with congenital heart disease.Translational pediatrics · 2018Review
- The Long Noncoding RNA Landscape of the Ischemic Human Left Ventricle.Circulation. Cardiovascular genetics · 2017Article
- Mitochondrial transplantation for therapeutic use.Clinical and translational medicine · 2016Review
- Quantitative proteomic analysis in HCV-induced HCC reveals sets of proteins with potential significance for racial disparity.Journal of translational medicine · 2013Article
- Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury.American journal of physiology. Heart and circulatory physiology · 2013Article
- Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium.American journal of physiology. Heart and circulatory physiology · 2013Article
- Microarray and proteomic analysis of the cardioprotective effects of cold blood cardioplegia in the mature and aged male and female.Physiological genomics · 2012Article
- Genomes, proteomes, and the central dogma.Circulation. Cardiovascular genetics · 2011Article
- What can we learn about cardioprotection from the cardiac mitochondrial proteome?Cardiovascular research · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Cardioplegia is used to partially alleviate the effects of surgically induced global ischemia injury; however, the molecular mechanisms involved in this cardioprotection remain to be elucidated. To improve the understanding of the molecular processes modulating the effects of global ischemia and the cardioprotection afforded by cardioplegia, we constructed rabbit heart cDNA libraries and isolated, sequenced, and identified a compendium of nonredundant cDNAs for use in transcriptomic and proteomic analyses. New Zealand White rabbits were used to compare the effects of global ischemia and cardioplegia compared with control (nonischemic) hearts. The effects of RNA and protein synthesis on the cardioprotection afforded by cardioplegia were investigated separately by preperfusion with either alpha-amanitin or cycloheximide. Our results demonstrate that cardioplegia partially ameliorates the effects of global ischemia and that the cardioprotection is modulated by RNA- and protein-dependent mechanisms. Transcriptomic and proteomic enrichment analyses indicated that global ischemia downregulated genes/proteins associated with mitochondrial function and energy production, cofactor catabolism, and the generation of precursor metabolites of energy. In contrast, cardioplegia significantly increased differentially expressed genes/proteins associated with the mitochondrion and mitochondrial function and significantly upregulated the biological processes of muscle contraction, involuntary muscle contraction, carboxylic acid and fatty acid catabolic processes, fatty acid beta-oxidation, and fatty acid metabolic processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.