ArticleGastroenterology2009
Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats.
Article in Gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Lactated Ringers Does Not Reduce SIRS in Acute Pancreatitis Compared to Normal Saline: An Updated Meta-Analysis.Digestive diseases and sciences · 2022Pooled it
- Post-endoscopic retrograde cholangiopancreatography pancreatitis: A systematic review for prevention and treatment.World journal of gastroenterology · 2019Pooled it
- Continuous Infusion of Fluid Hydration Over 24 Hours Does Not Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.Digestive diseases and sciences · 2022Trial
- Association of early crystalloid type with mortality and costs in acute pancreatitis: a nationwide cohort study.Journal of gastroenterology · 2026Article
- Fluid therapy strategies in acute pancreatitis: Randomized controlled trial comparing dextran and Ringer's lactate.World journal of gastrointestinal surgery · 2025Article
- Advances in the Management of Fluid Resuscitation in Acute Pancreatitis: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1/Parkin pathway in caerulein‑treated pancreatic ductal epithelial cellsExperimental and therapeutic medicine · 2024Article
- Microenvironment of pancreatic inflammation: calling for nanotechnology for diagnosis and treatment.Journal of nanobiotechnology · 2023Review
- L-arginine-induced pancreatitis aggravated by inhibiting NaThe Journal of veterinary medical science · 2023Article
- Lactated Ringer's Solution Reduces Severity, Mortality, Systemic and Local Complications in Acute Pancreatitis: A Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Intravenous fluid therapy in patients with severe acute pancreatitis admitted to the intensive care unit: a narrative review.Annals of intensive care · 2022Review
- Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis.Molecular medicine (Cambridge, Mass.) · 2022Article
- Pancreas-specific CHRM3 activation causes pancreatitis in mice.JCI insight · 2021Article
- The challenge of prognostic markers in acute pancreatitis: internist's point of view.Journal, genetic engineering & biotechnology · 2021Article
- Emerging Therapies to Prevent Post-ERCP Pancreatitis.Current gastroenterology reports · 2020Review
- Genetics, Cell Biology, and Pathophysiology of Pancreatitis.Gastroenterology · 2019Review
- Pancreatitis in Children.Gastroenterology · 2019Review
- New Advances in the Treatment of Acute Pancreatitis.Current treatment options in gastroenterology · 2019Review
- Update on the Prevention of Post-ERCP Pancreatitis.Current treatment options in gastroenterology · 2018Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsProtease activation within the pancreatic acinar cell is a key early event in acute pancreatitis and may require low pH intracellular compartments. Clinical studies suggest that acidosis may affect the risk for developing pancreatitis. We hypothesized that exposure to an acid load might sensitize the acinar cell to secretagogue-induced pancreatitis.
methodsSecretagogues (cerulein, carbachol, and bombesin) can induce protease activation in acinar cells at high (100 nmol/L, 1 mmol/L, and 10 micromol/L, respectively) but not at physiologically relevant concentrations. The effects of decreasing extracellular pH (pHe) in early secretagogue-induced pancreatitis (zymogen activation and injury) were examined in rats (1) in vitro with isolated acini and (2) in vivo with an acid challenge.
resultsIn acini, lowering pHe from 7.6 to 6.8 enhanced secretagogue-induced zymogen activation and injury, but did not affect secretion. For cerulein, this sensitization was seen over a range of concentrations (0.01-100.00 nmol/L). However, reduced pHe alone had no effect on zymogen activation, amylase secretion, or cell injury. We have reported that zymogen activation is mediated by the vacuolar ATPase (vATPase), a proton transporter. vATPase inhibition, using concanamycin (100 nmol/L), blocked the low pHe effects on zymogen activation. An acute acid load given in vivo enhanced cerulein-induced (50 microg/kg) trypsinogen activation and pancreatic edema.
conclusionThese studies suggest that acid challenge sensitizes the pancreatic acinar cell to secretagogue-induced zymogen activation and injury and may increase the risk for the development and severity of acute pancreatitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.