ArticleFEBS letters2009
Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency.
Article in FEBS letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Deciphering the molecular landscape of hepatopancreatic necrosis disease in Eriocheir sinensis using RNA-Seq meta-analysis.Genes & genomics · 2026Pooled it
- SiRNA-mediated Silencing of the RPS19 Gene Induces Apoptosis and Inhibits Cell Cycle Progression in Chronic Myeloid Leukemia Cells.International journal of molecular and cellular medicine · 2024Article
- Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia.FEBS open bio · 2022Article
- Translation of upstream open reading frames in a model of neuronal differentiation.BMC genomics · 2019Article
- A functional assay for the clinical annotation of genetic variants of uncertain significance in Diamond-Blackfan anemia.Human mutation · 2018Article
- Role of ribosomal protein mutations in tumor development (Review).International journal of oncology · 2016Review
- PRPF8 defects cause missplicing in myeloid malignancies.Leukemia · 2015Article
- Article
- Elevation of receptor tyrosine kinases by small molecule AKT inhibitors in prostate cancer is mediated by Pim-1.Cancer research · 2013Article
- RNA binding protein/RNA element interactions and the control of translation.Current protein & peptide science · 2012Review
- Article
- The effects of EBV transformation on gene expression levels and methylation profiles.Human molecular genetics · 2011Article
- PIM1 kinase is destabilized by ribosomal stress causing inhibition of cell cycle progression.Oncogene · 2010Article
- Ribosomal protein S19 binds to its own mRNA with reduced affinity in Diamond-Blackfan anemia.Blood cells, molecules & diseases · 2010Article
- A single-nucleotide deletion in the POMP 5' UTR causes a transcriptional switch and altered epidermal proteasome distribution in KLICK genodermatosis.American journal of human genetics · 2010Article
- Article
- Diamond Blackfan Anemia at the Crossroad between Ribosome Biogenesis and Heme Metabolism.Advances in hematology · 2010Article
- Ribosomal protein S19 and S24 insufficiency cause distinct cell cycle defects in Diamond-Blackfan anemia.Biochimica et biophysica acta · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ribosomal protein S19 (RPS19) is mutated in patients with Diamond-Blackfan anemia (DBA). We hypothesized that decreased levels of RPS19 lead to a coordinated down-regulation of other ribosomal (r-)proteins at the subunit level. We show that small interfering RNA (siRNA) knock-down of RPS19 results in a relative decrease of small subunit (SSU) r-proteins (S20, S21 and S24) when compared to large subunit (LSU) r-proteins (L3, L9, L30 and L38). This correlates with a relative decrease in 18S rRNA with respect to 28S rRNA. The r-protein mRNA levels remain relatively unchanged indicating a post transcriptional regulation of r-proteins at the level of subunit formation.
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Registered trials
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