ReviewExperimental and molecular pathology2009
Prospects for clinical cancer metabolomics using stable isotope tracers.
Review in Experimental and molecular pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Photolysis of COJournal of the American Chemical Society · 2026Article
- Rapid analysis of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) isotopologues in stable isotope-resolved metabolomics (SIRM) using direct infusion nanoelectrospray ultra-high-resolution Fourier transform mass spectrometry (DI-nESI-UHR-FTMS).Analytica chimica acta · 2021Article
- Distinct nitrogen isotopic compositions of healthy and cancerous tissue in mice brain and head&neck micro-biopsies.BMC cancer · 2021Article
- Improved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry.Analytica chimica acta · 2019Article
- Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences.Journal of proteome research · 2016Article
- Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells.Cancer & metabolism · 2016Article
- Modeling cancer metabolism on a genome scale.Molecular systems biology · 2015Review
- Regulation of mammalian nucleotide metabolism and biosynthesis.Nucleic acids research · 2015Review
- isoMETLIN: a database for isotope-based metabolomics.Analytical chemistry · 2014Article
- A review of applications of metabolomics in cancer.Metabolites · 2013Article
- Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells.Metabolomics : Official journal of the Metabolomic Society · 2012Article
- Clinical metabolomics: the next stage of clinical biochemistry.Blood transfusion = Trasfusione del sangue · 2012Review
- Stable isotope-resolved metabolomics and applications for drug development.Pharmacology & therapeutics · 2012Review
- Isotope enhanced approaches in metabolomics.Advances in experimental medicine and biology · 2012Review
- Stable isotope resolved metabolomics of lung cancer in a SCID mouse model.Metabolomics : Official journal of the Metabolomic Society · 2011Article
- Article
- Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer.Omics : a journal of integrative biology · 2011Review
- Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging.Journal of the American Chemical Society · 2009Article
- Metabolic profiling identifies lung tumor responsiveness to erlotinib.Experimental and molecular pathology · 2009Article
- Mathematical modeling of folate metabolism.Wiley interdisciplinary reviews. Systems biology and medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Metabolomics provides a readout of the state of metabolism in cells or tissue and their responses to external perturbations. For this reason, the approach has great potential in clinical diagnostics. For more than two decades, we have been using stable isotope tracer approaches to probe cellular metabolism in greater detail. The ability to enrich common compounds with rare isotopes such as carbon ((13)C) and nitrogen ((15)N) is the only practical means by which metabolic pathways can be traced, which entails following the fate of individual atoms from the source molecule to products via metabolic transformation. Changes in regulation of pathways are therefore captured by this approach, which leads to deeper understanding of the fundamental biochemistry of cells. Using lessons learned from pathways tracing in cells and organs, we have been applying this methodology to human cancer patients in a clinical setting. Here we review the methodologies and approaches to stable isotope tracing in cells, animal models and in humans subjects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.